Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.31 (
beta-glucuronidase
)
7,680
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We have studied, as a possible marker of cholinergic neurons, the acetylcholinesterase (AChE) activity in cerebrospinal fluid (CSF) of 21
SDA
patients and 9 controls of similar age with no neurological disease. The AChE activities were significantly lower in the
SDA
patients compared to the controls. The AChE activities were also lowered in the most severely demented patients compared to those who were less severely demented but the difference was not statistically significant. As a potential glia marker,
beta-glucuronidase
activity in CSF was studied, but no significant difference was found in the activities of the
SDA
patients compared to the controls. The reduced AChE activities in the CSF of the
SDA
patients may be related to the loss of cholinergic neurons or disturbed cholinergic metabolism in the brain.
...
PMID:Acetylcholinesterase activities in cerebrospinal fluid of patients with senile dementia of Alzheimer type. 731 92
