Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.31 (
beta-glucuronidase
)
7,680
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effect of cytochalasin B on phospholipid metabolism and
beta-glucuronidase
extrusion by polymorphonuclear leukocytes from guinea
pid
peritoneal exudates has been studied. Cytochalasin B inhibited the engulfing of starch granules by leukocytes, but it enhanced the incorporation of 32-Pi into phosphatidic acid and the phosphoinositidesmit also stimulated the release of
beta-glucuronidase
into the incubation medium in the presence or absence of starch granulesmkinetic studies showed that the effects of cytochalasin B on 32-Pi incorporation into phosphatidic acid and the phosphoinositides, and the release of
beta-glucuronidase
into the extracellular medium were comparablempulse-chase experiment revealed that cytochalasin B did not stimulate the isotopic decay of prelabeled lipids, indicating that cytochalasin B increased the radiophosphorus activity of phosphatidic acid and the phosphoinositides by increasing the synthesis of these lipidsmthe incorporation of myo-[2-3H]inositol into the phosphoinositides was also enhanced in the presence of cytochalasin B, but the incorporation of [methyl-14-C] choline into phosphatidylcholine and sphingogonyelin was unchanged;
...
PMID:Cytochalasin B: effect on phospholipid metabolism and lysosomal enzyme release by leukocytes;. 112 22
