Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.31 (
beta-glucuronidase
)
7,680
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
N-acetyl-beta-glucosaminidase (EC 3.2.1.30, recommended name beta-N-Acetylglucosaminidase) was found to be a constituent of human cardiac lysosomes.
beta-glucuronidase
was also found in this tissue, while lysozyme, an enzyme present in leucocyte lysosomes, was not detectable in the heart. The activities of both N-acetyl-beta-glucosaminidase and
beta-glucuronidase
were elevated in plasma during the first 24 h after the onset of chest pain in patients with
acute myocardial infarction
and the peak levels of N-acetyl-beta-glucosaminidase correlated well with those of creatine kinase. N-acetyl-beta-glucosaminidase showed a further rise in plasma activity which gave a peak at 72 h after the onset of chest pain and this was accompanied by a rise in lysozyme activity. It is suggested that lysosome disruption caused by myocardial cell necrosis was responsible for the initial rise in plasma lysosomal enzyme activity and that the subsequent inflammatory reaction gave rise to the second peak.
...
PMID:Plasma lysosomal enzyme activity in acute myocardial infarction. 64 16
To determine the effect of
acute myocardial infarction
(
AMI
) on serum and urinary activity of beta-galactosidase and
beta-glucuronidase
(lysosomal enzymes) 40 patients were studied. Eighteen patients had
acute myocardial infarction
and 22 were assigned as controls. Three of the 18 patients with
acute myocardial infarction
died within 5 to 10 days after hospitalization. Although the serum and urinary
beta-glucuronidase
and serum beta-galactosidase activity was higher in patients with
acute myocardial infarction
when compared with the control subjects these differences did not achieve statistical significance. However, the mean values of urinary beta-galactosidase in the control and acute MI groups were 158.68 and 333.3 nmol/mg creatinine/hr, respectively (p less than 0.046). These findings indicate that there is a significant increase in the urine beta-galactosidase activity during the early phases of
acute myocardial infarction
.
...
PMID:Serum and urinary beta-galactosidase and beta-glucuronidase activity in patients with acute myocardial infarction. 681 68
