Gene/Protein
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Drug
Enzyme
Compound
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Gene/Protein
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Target Concepts:
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Query: EC:3.2.1.31 (
beta-glucuronidase
)
7,680
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Alveolar hydatid
cysts (LCM) grow progressively and contribute significantly to the morbidity of hydatid-hosts. To examine whether modifications in immune effector parameters correlate with the pattern of LCM growth, in vivo experiments were carried out in C57BL/6J mice infected intraperitoneally with LCM. Immigrant peritoneal and intra-LCM leukocytes were tested for the loss of cell surface receptors, membrane-bound and internalized immune complexes (ICs) and lysosomal enzyme contents during the restrictive and progressive growth phases of the LCM. The proportion of Fc and C3b receptor-bearing intra-LCM leukocytes decreased 2-fold and 31 to 72% of the leukocytes contained ICs during the progressive phase of the LCM. Acid phosphatase and
beta-glucuronidase
activities of macrophages declined sharply during the restrictive phase but they gradually increased as the infection progressed. IC-mediated dysfunction of effector leukocytes and modulation of antibody dependent cell cystolysis mechanism are discussed in murine hydatidosis.
...
PMID:Characterization of the inflammatory cells in progressing tumor-like alveolar hydatid cyst. 2. Cell surface receptors, endocytosed immune complexes and lysosomal enzyme content. 624 Aug 19
