Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.31 (beta-glucuronidase)
 7,680 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Inflammatory exudates were obtained from polyester sponges which had been implanted subcutaneously in rats four days previously. This material was found to be anti-inflammatory when injected into other rats in which carrageenan pleurisy had been induced. At a dose of 600 mg kg-1 exudate inhibited the formation of pleural effusion, emigration of both neutrophils and mononuclear cells and the accumulation of beta-glucuronidase and lactic dehydrogenase. The same dose of sponge exudate did not however inhibit the increased vascular permeability induced in the rat skin or rat foot following injection of 5-hydroxytryptamine, histamine, prostaglandin E1, or bradykinin. Furthermore sponge exudate did not reduce the haemolytic complement titre of rat serum either in vivo or in vitro. The possible mechanism of anti-inflammatory action of exudate is discussed.
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PMID:Some biological and pharmacological properties of inflammatory exudates. 1 58

The antiinflammatory effect of 764-3 was investigated in rat models of lung inflammation and pleurisy induced by bleomycin intratracheal instillation and carrageenan intrapleural cavity injection respectively. 4 mg/100 g BW.d 764-3 hypodermal injection significantly inhibited the lung inflammatory changes in bleomycin treated rats. Compared with the experimental group, lung index, histamine content in lung tissue and in bronchoalveolar lavage fluid (BALF), number of PMN in BALF and BALF beta-glucuronidase activity significantly deceased in the therapeutic rats. 8 mg/100 g BW 764-3 intramuscular injection significantly inhibited the volume, number of PMN, protein content and beta-glucuronidase activity increase in carrageenan-induced pleural exudate fluid. The antiinflammatory effect of 8 mg/100 g BW 764-3 was equal to that of 3 mg/100 g BW hydrocortisone. 4 mg/100 g BW 764-3 injection significantly inhibited the increases in PMN numbers and beta-glucuronidase activity in pleural exudate fluid. 2 mg/100 g BW 764-3 injection significantly inhibited the PMN increase in pleural exudate fluid only. 1 mg/100 g BW 764-3 injection showed no antiinflammatory effect. When 764-3 was administered orally, the antiinflammatory effect was unsatisfactory. 5 mg/100 mg BW 764-3 significantly inhibited the volume, number of PMN, protein content and beta-glucuronidase activity of carrageenan-induced pleural exudate fluid. 2.5 mg/100 g BW 764-3 significantly inhibited the volume and protein content increases in pleural exudate fluid. But 3.5 mg/100 g BW 764-3 showed no antiinflammatory effect. The authors indicate that the antiinflammatory effect of orally administered 764-3 was not stable.
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PMID:[Protective effect of 764-3 on experimental inflammation]. 137 11

In rat carrageenin pleurisy, both steroidal and non-steroidal anti-inflammatory drugs (SAID and NSAID respectively) produced a dose-related reduction of exudate volume and of prostaglandin (PG)E2 contents in the exudate at 3 h after carrageenin. However, with the exception of ketoprofen, administration of all the NSAID in low doses resulted in a significant reduction of PGE2 contents with no significant reduction in exudate volume. NSAID reduced leucocyte number and total activities of lysosomal enzymes in the exudate at 3 h after carrageenin only at the higher doses, while SAID did so in a dose-related manner. Both SAID and NSAID reduced the arylsulfatase activity released into the exudate (free activity) dose-relatedly but not the free activity of beta-glucuronidase at 3 h after carrageenin. However, some drug treatments resulted in a lower reduction in free arylsulfatase activity than in exudate volume. These results suggest that the reduction of PGE2 contents may be the main contribution to the anti-exudative activities of anti-inflammatory drugs in rat carrageenin pleurisy and that this effect may be complemented by the reduction of free activity of lysosomal enzymes such as arylsulfatase.
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PMID:Effects of several anti-inflammatory drugs on the various parameters involved in the inflammatory response in rat carrageenin-induced pleurisy. 658 58