Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.31 (
beta-glucuronidase
)
7,680
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
beta-Glucuronidase activity increased in the serum of BALB/c mice during the growth of the IgM-secreting
plasmacytoma
, TEPC-183. The increase appeared to correlate with tumor burden. The
beta-glucuronidase
activity in tissue homogenates of spleen, liver, and kidney from tumor-bearing mice also increased significantly compared to the levels found in corresponding tissues from normal control mice. Assays of lysosomal and microsomal fractions from livers of TEPC-bearing mice indicated that approximately 70% of the enzyme activity was associated with the lysosomal fraction and the remainder with the microsomal fraction. A similar distribution was found in homogenates prepared from the
plasmacytoma
itself. In contrast to this the
beta-glucuronidase
activity in livers from normal BALB/c mice is nearly equally distributed between lysosomal and microsomal fractions.
...
PMID:The effect of TEPC-183 plasmacytoma growth on beta-glucuronidase activity in serum and tissues of tumor-bearing mice. 665 89
