Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.2.1.31 (beta-glucuronidase)
 7,680 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pituitary glands grafted under the kidney capsule provide a continuous supply of prolactin due to the absence of hypothalamic inhibitory factor. Increase in the level of prolactin in the rat may affect availability of hormone for reproductive function. Single pituitaries were transplanted under the kidney capsule of male rats. After six weeks of the transplant, the recipient rats were sacrificed and trophic activity of testosterone and intratesticular functions were assessed. The weights of ventral prostate and seminal vesicles, full and empty, showed significant increase from the control value. The activity of beta-glucuronidase in kidney, an androgen inducible enzyme, also increased in comparison with the control value. Incorporation of 32P in the nucleic acid fraction showed an increase. The increased rate of testosterone production and an alteration in spermatogenesis was associated with increased activity of acid phosphatase and decreased activity of beta-glucuronidase. The active mediation of lysosomal enzyme in testicular function as altered by prolactin was indicated.
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PMID:Effect of ectopic pituitary homograft on the physiological status of rat testis. 395 89

In vitro protein synthesis, lysosomal hydrolases activity and peroxidase activity in the anterior pituitary were estimated in adult male rats treated with 50 micrograms of estradiol benzoate (EB) for 1 day or 7 days. Pituitary protein synthesis, protein and RNA content increased after 7 days. A significant increase in total and membrane-bound acid phosphatase was noted after 1 day or 7 days of EB treatment whereas total beta-glucuronidase activity decreased in both 1 and 7 day group. Cathepsin activity increased after 7 days and pituitary peroxidase system did not change by EB treatment. These findings suggest that immediate change in the enzyme milieu may be one of the first reactions by which EB expresses its feedback control.
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PMID:Estradiol benzoate induced changes in protein synthesis and lysosomal hydrolases in the pituitary of male rats. 631 2