Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.2.1.31 (beta-glucuronidase)
 7,680 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The present study was designed to investigate the chemical properties of the aggression-promoting cues present in bladder urine of male mice. The results of the first experiment confirmed earlier work by demonstrating the presence of an aggression-promoting chemosignal in bladder urine. In Experiment 2, behavioral assays were separately performed on the organic and aqueous layers of bladder urine obtained by repeated dichloromethane extractions. Only the combined organic layers of the initial three extractions demonstrated behavioral activity. A fourth extraction showed no behavioral activity for both organic and aqueous layers. However, the findings of Experiment 3 showed that incubation of the aqueous layer from the third CH2Cl2 extraction in beta-glucuronidase can free additional aggression-promoting cues into a subsequent CH2Cl2 extraction. It is concluded that two forms of the aggression-promoting chemosignal are present in bladder urine. One is lipophilic and behaviorally active, whereas the other is conjugated, possessing latent chemosignal properties.
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PMID:beta-Glucuronidase activation of latent aggression-promoting cues in mouse bladder urine. 689 69

A genetic model of pheromonally mediated aggression in laboratory male mice, which has been developed over the past decade, is reviewed and integrated with recent developments in the neurobiology of olfaction and the chemistry of pheromones in Mus musculus. Experimental data strongly support the possibility of enzymatic activation of aggression promoting and inhibiting pheromones by beta-glucuronidase (EC 3.2.1.31). These findings introduce important questions as to the involvement of beta-GLU genes (Gus and Eg on chromosomes 5 and 8, respectively) in the determination of urine odor profiling. The discovery of two neuroanatomically, and functionally distinct, olfactory structures in 1975 led the way for direct selection of olfactory bulb relay neurons, medial amygdala nucleus neurons and TIDA-neurons for analysis of the genetic mechanisms involved in pheromonal action on aggressive and other olfactory mediated social behaviors in rodents.
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PMID:The genetics of pheromonally mediated intermale aggression in mice: current status and prospects of the model. 826 61