Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.26 (
invertase
)
4,927
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We determined along the small intestine of young and adult rabbits the activities of lactase (
LPH
) and
sucrase
(SI), the levels of their cognate mRNAs, and examined the in vitro biosynthesis of
LPH
and pro-SI. Lactase activity is low in the proximal 1/3 of the intestine, whereas the mRNA levels are high. However, the rates of biosynthesis of the
LPH
forms correlated well with the steady-state levels of
LPH
mRNA in all segments, indicating that factor(s) acting post-translationally produce a decline in brush border
LPH
in the proximal small intestine. These factor(s) are not involved in the processing of pro-
LPH
to mature
LPH
, since the relative amounts of the various forms of
LPH
are almost the same along the small intestine. Unexpectedly, we find that also for SI the ratio of activity to mRNA is low in proximal intestine. The biosynthesis of pro-SI correlates with the steady-state levels of its mRNA. Hence, the steady-state levels of
LPH
and SI along the small intestine are regulated both by mRNA levels and by posttranslational factor(s).
...
PMID:The levels of lactase and of sucrase-isomaltase along the rabbit small intestine are regulated both at the mRNA level and post-translationally. 144 47
