Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.26 (invertase)
 4,927 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

alpha-Glucosidase (AGH) inhibitory study by natural anthocyanin extracts was done. As the result of a free AGH assay system, 12 anthocyanin extracts were found to have a potent AGH inhibitory activity; in particular, Pharbitis nil (SOA) extract showed the strongest maltase inhibitory activity, with an IC(50) value of 0.35 mg/mL, as great as that of Ipomoea batatas (YGM) extract (IC(50) = 0.36 mg/mL). Interestingly, neither extract inhibited the sucrase activity at all. For the immobilized assay system, which may reflect the pharmacokinetics of AGH at the small intestine, SOA and YGM extracts gave more potent maltase inhibitory activities than those of the free AGH assay, with IC(50) values of 0.17 and 0.26 mg/mL, respectively. Both extracts also inhibited alpha-amylase action, indicating that anthocyanins would have a potential function to suppress the increase in postprandial glucose level from starch.
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PMID:alpha-Glucosidase inhibitory action of natural acylated anthocyanins. 1. Survey of natural pigments with potent inhibitory activity. 1130 51

Ingestion of concentrated sucrose solutions causes sickness in sucrase-deficient birds. As a result, some suggest that sucrose may represent an environmentally safe avian repellent. In the present experiments, we compared the repellency of sucrose to that of methyl anthranilate (MA), a known avian repellent. We also tested mixtures of sucrose and MA to investigate whether repellency could be enhanced, relative to sucrose or MA presented alone. The results showed that the MA was strongly avoided in both drinking and feeding trials. Conversely, only high sucrose concentrations were avoided, and only in drinking trials. No combination of MA and sucrose was as effective as MA alone. We conclude that sucrose is not sufficiently aversive to serve as an avian repellent in the field.
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PMID:Interaction Between Sensory and Postingestional Repellents in Starlings: Methyl Anthranilate and Sucrose. 2775 29