Gene/Protein
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Drug
Enzyme
Compound
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Query: EC:3.2.1.26 (
invertase
)
4,927
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Anthocyanin
accumulation specifically depends on sucrose (Suc) signaling/levels. However, the gene cascades specifically involved in the Suc signaling/level-mediated anthocyanin biosynthetic pathway are still unknown.
Arabidopsis ANGUSTIFOLIA3
(
AN3
), a transcription coactivator, is involved in the regulation of leaf shape and drought tolerance. Recently, an
AN3-CONSTITUTIVE PHOTOMORPHOGENIC 1
gene cascade has been reported to regulate the light signaling-mediated anthocyanin accumulation. Target gene analysis indicates that
AN3
is associated with the
YODA
(
YDA
) promoter, a mitogen-activated protein kinase kinase kinase,
in vivo
for inducing anthocyanin accumulation. Indeed, loss-of-function mutants of
YDA
showed significantly increased anthocyanin accumulation.
YDA
mutation can also suppress the decrease in
an3-4
anthocyanin accumulation. Further analysis indicates that the mutations of
AN3
and
YDA
disrupt the normal Suc levels because of the changes of
invertase
activity in mutants of
an3
or
yda
, which in turn induces the alterations of anthocyanin accumulation in mutants of
an3
or
yda
via unknown regulatory mechanisms.
...
PMID:The
Arabidopsis ANGUSTIFOLIA3
-
YODA
Gene Cascade Induces Anthocyanin Accumulation by Regulating Sucrose Levels. 2869 16
The disaccharide Suc cannot be utilized directly; rather, it is irreversibly hydrolyzed by
invertase
to the hexoses Glc and Fru to shape plant growth. In this context, Glc controls the stability of the transcription factor Ethylene-Insensitive3 (EIN3) via the function of Hexokinase1 (HXK1), a Glc sensor. Thus,
invertase
, especially the major neutral cytosolic
invertase
(CINV), constitutes a key point of control for plant growth. However, the cognate regulatory mechanisms that modulate CINV activity remain unclear. Here, we demonstrate that in Arabidopsis (
Arabidopsis thaliana
), EIN3 binds directly to both the promoters of
Production of
Anthocyanin
Pigment1
(
PAP1
) and
Phosphatidylinositol Monophosphate 5-Kinase 9
(
PIP5K9
), repressing and enhancing, respectively, their expression. Subsequently, PAP1 binds directly to and promotes transcription of the
Cytosolic Invertase1
(
CINV1
) promoter, while PIP5K9 interacts with and negatively regulates CINV1. The accumulated CINV1 subsequently hydrolyzes Suc, releasing the sequestered signaling cue, Glc, which has been shown to negatively regulate the stability of EIN3 via HXK1. We conclude that a CINV1-Glc-HXK1-EIN3-PAP1/PIP5K9-CINV1 loop contributes to the modulation of CINV1 activity regulating root growth by Glc signaling.
...
PMID:Cytosolic Invertase-Mediated Root Growth Is Feedback Regulated by a Glucose-Dependent Signaling Loop. 3282 66
