Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.26 (invertase)
 4,927 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Functional adaptation of the villus brush border and crypt have been evaluated preceding and following jejunoileal bypass for morbid obesity. Before surgery, 26 of 101 patients who were at least 100% above their ideal weight were randomly included into the study group, and control tissue specimens were collected from the jejunum and ileum. When five patients required revision of the bypass, jejunal and ileal specimens were collected from the functional (included) and nonfunctional (excluded) segments. At 19.2 +/- 5.0 (SD) months following the bypass procedure, there was an increase in alkaline phosphatase, sucrase and thymidine kinase specific activities within the functional remnants; the included ileum demonstrated a greater degree of adaptation than the included jejunum. In the nonfunctional jejunum there was a decrease in alkaline phosphatase and thymidine kinase specific activities, whereas no statistical alteration in mucosal enzyme activities occurred within the nonfunctional ileum. Serum total protein concentrations and serum magnesium levels were also evaluated before bypass and at revision. Mean serum magnesium levels became decreased, whereas serum total protein concentrations were not altered.
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PMID:Functional adaptation of the intestinal mucosal enzymes after jejunoileal bypass for morbid obesity. 66 64

Morphologic and functional adaptations of the functioning intestine were evaluated in 41 patients before and after biliopancreatic bypass for morbid obesity. This surgical procedure diverts pancreatobiliary secretions via the duodenum and the jejunum into the colon, the remaining small intestine being anastomosed to the stomach after antrectomy. In the proximal ileum there was an 80% increase of the height of villi; the specific activities of maltase, sucrase, and aminopeptidase in brush border membranes remained unaffected, and that of lactase tended to decrease. In the distal ileum villi heights increased only by 58%, and disaccharidase activities (except for maltase) were slightly enhanced. In the colon the mucosa displayed, in some patients, focal appearance of true villi, and brush border enzyme activities increased concomitantly. We conclude that biliopancreatic bypass induces an adaptation of all intestinal segments of the functioning intestine; this adaptation tends to compensate for the shortening of the gut continuity.
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PMID:Small-intestinal and colonic changes after biliopancreatic bypass for morbid obesity. 310 Nov 67

Previous work in our laboratory and in others suggest that protein malnutrition plays an important role in the pathogenesis of hepatic dysfunction after jejunoileal bypass for morbid obesity. This experimental study was undertaken to attempt to correlate hepatic dysfunction (the criterion used was the bromsulphalein clearance) to morphological and enzymatic adaptation of the functioning intestine in the rat. It was observed that the period of impaired bromsulphalein clearance is concomitant with a slight ileal morphological adaptation and especially with a period of selective adaptation of maltase and sucrase activities, whereas there is no increase in aminopeptidase activity. These data support the hypothesis that after jejunoileal bypass a preferential absorption of carbohydrates along with a protein deficiency state could occur and as in kwashiorkor it results in an impaired nutritional status, a major contributing factor to bypass-induced liver injury.
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PMID:Imbalance in brush border enzyme activities as a possible cause of hepatic dysfunction after jejunoileal bypass in the rat. 704 83