Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.26 (
invertase
)
4,927
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Brush border
sucrase
and alkaline phosphatase activities are considerably enhanced in the intestine of ascorbic acid deficient guinea-pigs. Similar increase in the uptake of D-glucose and L-alanine also occurs in chronic
vitamin C deficiency
. However the permeability of D-glucose and L-alanine in the intestine of animals fed with large doses of vitamin C is severely depressed, with a reduction in the levels of
sucrase
and alkaline phosphatase activities.
...
PMID:Effect of chronic hypo and hypervitaminosis C on the brush border enzymes and the intestinal uptake of glucose and alanine. 47 73
The effect of
vitamin C deficiency
on various enzymes of the intestinal epithelium has been studied in guinea pigs. Brush border
sucrase
and alkaline phosphatase activities were considerably enhanced (p less than 0.001), but leucine aminopeptidase levels were reduced in
scorbutic
animals compared to the control group. There was essentially no change in the activity of maltase under these conditions. Kinetic studies with
sucrase
and alkaline phosphatase in control and
scorbutic
animals revealed that augmentation of the enzyme activities in scurvy is due to enhanced enzyme contents. Lactate dehydrogenase, succinate dehydrogenase, glucose-6-phosphatase and Mg+2 ATPase also exhibited reduced activities in the intestine of vitamin-C-deficient animals. Observed alterations in the activities of intestinal enzymes in scurvy were restored to control levels upon feeding of vitamin C to
scorbutic
guinea pigs.
...
PMID:Alterations in the activities of intestinal enzymes in vitamin-C-deficient guinea pigs. 627 90
The effect of
vitamin C deficiency
on the digestive and absorptive functions of the gut has been investigated in guinea pigs. The absorption of D-glucose was significantly elevated, but that of L-leucine, L-alanine and L-lysine considerably depressed in the intestine of
scorbutic
guinea pigs compared to controls. The intestinal transport of vitamin B12 was also diminished. Activities of
sucrase
and alkaline phosphatase on the brush border were enhanced, but that of leucine aminopeptidase markedly reduced in
scorbutic
animals compared to controls. Maltase activity was unaffected in vitamin C deficient animals. Chemical analysis of the brush borders isolated from
scorbutic
animals revealed a considerable decrease in membrane protein, total lipids, phospholipids, and free cholesterol contents compared to control animals. In vivo 2-(14)C-acetate incorporation into membrane lipids suggested that the observed decrease in lipid components of the
scorbutic
membranes is due to reduced synthesis. Administration of ascorbic acid to
scorbutic
animals ameliorated the intestinal aberrations observed in scurvy.
...
PMID:Effect of vitamin C deficiency in guinea pigs on intestinal functions and chemical composition of brush border membrane. 730 86
