Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.23 (
beta-galactosidase
)
14,648
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Five cDNA clones for TAXREB proteins that bind to the tax-responsive enhancer element of human T-cell leukemia virus type I (HTLV-I) were isolated from a Jurkat cell cDNA library. The
beta-galactosidase
fusion proteins of three of these clones specifically recognized the domain C within the enhancer. One of the three cDNAs, encoding
TAXREB107
, contained an open reading frame with 288 amino acid residues. RNA blot analysis showed that the level of mRNA for
TAXREB107
increased transiently in Jurkat cells on treatment with TPA. Immunoblot analysis showed that polyclonal antibody against
TAXREB107
specifically recognized a 34-kD protein in Jurkat cells.
TAXREB107
may participate in tax-mediated trans-activation of transcription.
...
PMID:Isolation of a cDNA clone encoding DNA-binding protein (TAXREB107) that binds specifically to domain C of the tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I. 845 78
