Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.23 (
beta-galactosidase
)
14,648
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
An allele of mutation in the proteasome subunit gene Y7, y7-1, caused a temperature-sensitive growth in S. cerevisiae. One of the multi-copy suppressor genes for this growth defect was identical to
SSB1
, which encodes a 70-kDa heat shock cognate protein of the yeast. Introduction of the multi-copy
SSB1
gene into the y7-1 mutant cells suppressed defects in the degradation of X-
beta-galactosidase
(X = Arg or Pro) observed in the mutant cells. Thus, the
SSB1
protein, one of the chaperons of the yeast, facilitated intracellular protein degradation.
...
PMID:A 70-kDa heat shock cognate protein suppresses the defects caused by a proteasome mutation in Saccharomyces cerevisiae. 808 77
