Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.23 (
beta-galactosidase
)
14,648
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The genotoxic potentials of boric acid in Escherichia coli PQ37 was assessed along in the presence of
aflatoxin B1
using SOS chromotest. Boric acid induced
beta-galactosidase
synthesis on the tester bacteria both on the presence and absence of S9 activation mixture. Therefore, the inorganic acid may not require metabolic activation to be genotoxic for this bacteria. When present together with
aflatoxin B1
in the assay medium, boric acid increased the degree of
beta-galactosidase
synthesis induced by the maximal inducing concentration of
aflatoxin B1
before the toxin's activation. However, the degree of enzyme synthesis induced was significantly decreased when boric acid was present after aflatoxin activation. This suggests that boric acid may not interfere with nor block the expoxidation of
aflatoxin B1
. It may however interact with the expoxide thereby inhibiting its activity. Boric acid may be a genotoxin and could possibly act as a syngenotoxic and/or a cogenotoxic agent.
...
PMID:Individual and combined genotoxic response of boric acid and aflatoxin B1 in Escherichia coli PQ37. 948 15
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