Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.23 (
beta-galactosidase
)
14,648
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
During a simultaneous induction of three enzymes which are subject to catabolite repression (
beta-galactosidase
, tryptophanase and
amylomaltase
, or
beta-galactosidase
, tryptophanase and D-serine deaminase) in a batch culture, the rates of synthesis of
beta-galactosidase
and tryptophanase decreases, while the rates of synthesis of
amylomaltase
and D-serine deaminase remain unaffected. The addition of cAMP brings about a considerable increase of the rate of synthesis of D-serine deaminase and a partial synthesis rate increase of
beta-galactosidase
whihle the synthesis rate of tryptophanase remains lowered and the synthesis rate of
amylomaltase
remains unaffected. In a continuous culture
beta-galactosidase
, tryptophanase and D-serine deaminase are synthesized simultaneously at a maximum rate without mutual influence. The addition of cAMP increases the rate of synthesis of all three enzymes.
...
PMID:Simultaneous induction of three catabolic enzymes in Escherichia coli. 624 3
Pleiotropic carbohydrate-positive pseudorevertants have been isolated from a specific class of rho-crp double mutants of Escherichia coli carrying both defective transcription termination protein, rho, and cyclic AMP receptor protein. The modulation of catabolite repression of
beta-galactosidase
,
amylomaltase
, and tryptophanase has been studied in the pseudorevertants. It has been found that these mutants exhibit catabolite repression. Because catabolite-sensitive operons can be expressed in the absence of functional cyclic AMP receptor protein, this would suggest on the one hand that the cyclic AMP-receptor protein complex is not the exclusive mediator of catabolite repression and on the other hand that rho might be involved in the regulation of catabolite-sensitive operons.
...
PMID:Catabolite repression in Escherichia coli mutants lacking cyclic AMP receptor protein. 625 66
