Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.23 (
beta-galactosidase
)
14,648
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Cysteamine (
MEA
) is comutagenic to methylnitrosourea (MNU) in E. coli AB 1157 but not in the nonadaptable mutant derivative ada-6 of that strain. The comutagenic action of
MEA
was eliminated by cysteine at low concentrations, which also lowered mutation frequencies in AB1157 but not in ada-6. In model experiments it was shown that cysteine counteracted the inhibition by
MEA
of
beta-galactosidase
induction in both bacterium strains. The comutagenic action of
MEA
is interpreted as being due to an inhibition of induction of methyltransferase during treatment with MNU.
...
PMID:Enhancement by cysteamine of N-methyl-N-nitrosourea mutagenesis in E. coli. 308 99
