Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.23 (
beta-galactosidase
)
14,648
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The mitochondrial ADP/ATP carrier in Saccharomyces cerevisiae is encoded by three independent genes.
AAC1
, AAC2, and AAC3. In this work, we analysed the 5' upstream region of
AAC1
by sequencing and by mapping the transcription initiation site of the gene. By monitoring the level of
AAC1
mRNA and the
beta-galactosidase
activity of
AAC1
-lacZ fusion constructs, we showed that expression of
AAC1
is subjected to regulation by oxygen. In contrast to the other two AAC genes, the effect of oxygen on
AAC1
is not mediated by heme and heme-dependent transcription factors. The
AAC1
expression was reduced eightfold in anaerobically grown cells compared to expression in cells grown aerobically, but it was not affected by the nature of carbon source used for growth. The data presented show that
AAC1
expression, while constitutive under all aerobic conditions tested, is repressed during anaerobiosis in a heme-independent manner.
...
PMID:Transcription of the AAC1 gene encoding an isoform of mitochondrial ADP/ATP carrier in Saccharomyces cerevisiae is regulated by oxygen in a heme-independent manner. 877 24
