Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.23 (
beta-galactosidase
)
14,648
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Understanding the biological mechanisms underlying aging and cancer predisposition remains a fundamentally important goal in biomedicine. The generation of a
PASG
hypomorphic mutant mouse model shows that
PASG
, an SNF2 family member, is essential for properly maintaining normal DNA methylation and gene expression patterns. Disruption of
PASG
leads to decreased incorporation of BrdU, accumulation of senescence-associated tumor suppressor genes, and increased senescence-associated
beta-galactosidase
as well as age-related phenotypes. These observations demonstrate that
PASG
plays a critical role in maintenance of tissue homeostasis, normal growth and longevity.
...
PMID:Altered epigenetic patterning leading to replicative senescence and reduced longevity. A role of a novel SNF2 factor, PASG. 1561 60
