Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.2.1.21 (beta-glucosidase)
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Human Gene/Protein
bile acid beta-glucosidase 13.2
cytosolic beta-glucosidase 12.3
Galactosidase, alpha 11.2
D-glucosyl-N-acylsphingosine glucohydrolase 11.2
GP27 10.9
beta-mannosidase 10.8
glucosidase, alpha 10.2
GBA3 10.2
MPS7 10.2
Glucosidase I 10.2
alpha-mannosidase 10.0
SAP-2 10.0
PPHA 9.9
FUCA2 9.8
lysosomal acid beta-galactosidase 9.8
alpha-glucosidase 9.7
Alpha-mannosidase 9.7
GBA2 9.6
alpha-galactosidase 9.5
Glucocerebrosidase 9.5
imiglucerase 9.4
SPN1 9.4
xylosidase 9.4
L-lactic dehydrogenase 9.3
GALA 9.3
alpha-L-fucosidase 9.3
N-acetyl-beta-glucosaminidase 9.2
protein O-fucosyltransferase 2 8.9
chitobiase 8.9
glucosidase I 8.7
trehalase 8.7
arylsulphatase 8.7
KF1 8.7
P270 8.6
lysosomal alpha-glucosidase 8.6
GH1 8.5
GS15 8.4
NAGK 8.4
GLP2 8.3
CMC1 8.3
ATP binding protein 8.2
COM1 8.2
AP2M1 8.2
beta-glucuronidase 8.2
arylsulfatase 8.1
Trehalase 8.1
LRR1 8.1
glucocerebrosidase 8.1
PTR3 8.1
B94 8.1
acid DNase 8.1
Maltase 8.0
LBA 8.0
lactase 8.0
lactase-phlorizin hydrolase 8.0
PKG1 7.9
midline 1 7.9
glucosidase 7.8
EF-1a 7.8
Protein interacting with C kinase 1 7.8
phosphomonoesterase 7.7
E170 7.7
EG1 7.7
Prosaposin 7.7
Hexosaminidase 7.7
Glucosidase II 7.6
P43 7.6
N-acetyl-beta-D-glucosaminidase 7.6
ATP1B1 7.6
UEV1A 7.5
NTG 7.5
hexosaminidase A 7.5
mannanase 7.4
CKIP-1 7.4
MMS2 7.4
sphingolipid activator proteins 7.3
OC-2 7.3
ERG25 7.3
HNP-2 7.3
Acid sphingomyelinase 7.3
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Disease
sphingolipidosis 9.6
Gaucher disease 9.1
Congenital ichthyosiform erythroderma 9.0
glycosphingolipidoses 8.4
favism 8.2
Witts 7.8
Niemann-Pick disease type B 7.7
Hers 7.6
Teratocarcinoma 7.5
gangliosidosis 7.3
LINCL 7.0
E. coli septicemia 6.8
Infantile neuronal ceroid lipofuscinosis 6.7
splenic disease 6.7
carcinoma of the uterus 6.7
lysosomal storage disease 6.4
mannosidosis 6.2
PSN 5.9
spirochetosis 5.7
LPI 5.7
enzyme deficiency 5.6
Lowe 5.6
Krabbe disease 5.5
Wolman disease 5.5
fucosidosis 5.5
hyperestrogenism 5.5
Niemann-Pick 5.4
Hurler 5.4
dental root 5.4
Sandhoff disease 5.3
hypersplenism 5.2
Tay-Sachs disease 5.2
sialidosis 5.2
PAL 5.1
familial disorder 5.1
GM1 gangliosidosis 5.0
orphan disease 5.0
Brock 4.9
MPS VII 4.9
protein deficiency 4.8
farmer's lung 4.7
cardiosclerosis 4.7
RP11 4.5
SDS 4.5
metachromatic leukodystrophy 4.5
HCI 4.5
Morquio 4.4
coccidioidomycosis 4.4
pH increased 4.4
NBS 4.4
Sweet 4.3
profound mental retardation 4.2
PME 4.1
scarlet fever 4.1
LAP 4.0
vitamin C deficiency 4.0
Farber 3.9
Stomach 3.9
Stomach 3.9
Stomach 3.9
MPS I 3.9
carcinosarcoma 3.8
Stomach 3.8
lactose intolerance 3.7
lipidosis 3.7
lipid disorder 3.6
AIN 3.6
Fabry 3.6
CLN3 3.6
pathological fracture 3.5
EDC 3.5
piles 3.5
osteosclerosis 3.5
CEP 3.4
RDA 3.4
vitamin E deficiency 3.4
epididymis 3.4
Fraser 3.3
Aujeszky's disease 3.3
CDA 3.3
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Symptom
not coping 8.0
autodigestion 4.9
microbial colonization 4.8
hepatosplenomegaly 4.1
Gastrointestinal symptoms 4.1
splenomegaly 3.4
myoclonus 3.2
starvation 3.0
bitter taste 2.8
agitation 2.7
bone pain 2.6
bloating 2.5
hepatomegaly 2.3
spasticity 2.2
acidity 2.2
Wind 1.9
diarrhea 0.8
hypotonia 0.7
tremor 0.7
exhaustion 0.5
dystonia 0.2
constipation -0.1
abdominal pain -0.1
thinning -0.2
stigma -0.5
functional recovery -0.5
collapse -0.6
ataxia -0.7
discomfort -1.2
discomfort -1.3
seizures -1.5
weakness -2.0
fatigue -2.4
anesthesia -2.5
pain -4.8
Drug
Thiocellobiose 13.2
Lycium fruit 11.7
Gluconolactone 10.6
Cerezyme 9.7
Ceredase 9.6
1-Deoxynojirimycin 9.2
Gardenia fruit 9.1
Cellulase 9.1
Cerezyme 9.0
Esculin 8.8
Histoplasmin 8.7
Pancreatin 8.4
H2SeO3 8.4
K201 8.2
Ipecac 8.0
FML 8.0
Lactase 7.9
Rhamnose 7.7
beta-Galactosidase 7.7
Potato starch 7.3
Swainsonine 6.9
Compound 18 6.4
Sodium citrate 6.4
Sodium citrate 6.4
Vanilla 6.1
Avicel PH 5.9
Rutin 5.9
Podophyllum 5.9
Monarch 5.8
Guar gum 5.7
Tween 40 5.6
lactose 5.6
Bifidobacterium 5.4
Cellulose acetate 5.2
ID2 5.1
Vitamin B 5.0
Mycophenolic acid 4.8
Galactose 4.8
Limonene 4.7
Lactose 4.7
Pronase 4.5
MgSO4 4.2
NAG 4.2
Ethanol 4.2
CoCl2 4.0
CoCl2 4.0
Fructose 3.9
Gel 3.8
FeCl3 3.8
Carotenoid 3.7
Glycerol 3.7
HCH 3.5
Fluorescein 3.4
Monensin 3.3
Asn 3.3
DMAP 3.1
L-tyrosine 3.0
Serum albumin 3.0
Fluorescein 3.0
CaCl2 2.9
CaCl2 2.9
CCL 2.9
ZnCl2 2.9
ZnCl2 2.9
CaCl2 2.9
ABC 2.7
Prednisolone 2.7
Acacia 2.6
Diurnal 2.5
Gelatin 2.5
NH3 2.5
niacin 2.4
EPI 2.2
DMI 2.2
citric acid 2.0
Nephron 1.7
IFN-beta 1.7
lysine 1.6
Kenyan 1.5
Leaf 1.4
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Enzyme
beta-glucosidase 13.2
hydroxymandelonitrile glucosyltransferase 13.2
coniferin beta-glucosidase 13.2
beta-glucosidase 13.2
beta-D-fucosidase 12.7
zeatin reductase 12.2
amygdalin hydrolase 12.2
EC 3.2.1.75 11.7
beta-xylosidase 11.4
raucaffricine glucosidase 11.2
EC 3.2.1.58 11.2
N-acetylgalactosaminidase 11.0
anthocyanin 5-aromatic acyltransferase 10.9
arabinosidase 10.8
vinorine synthase 10.7
phosphoamidase 10.5
alpha-L-rhamnosidase 10.4
5-methylthioribose kinase 10.2
methylsterol monooxygenase 10.2
cellobiohydrolase 10.2
alpha-L-fucosidase 10.1
isoflavone O-methyltransferase 10.1
ceramide trihexosidase 10.1
alpha-mannosidase 10.1
oligogalacturonate lyase 9.9
prunasin hydrolase 9.8
xanthan lyase 9.8
secologanin synthase 9.8
alpha-L-fucosidase 9.7
mannosyl-oligosaccharide glucosidase 9.7
alpha-L-fucosidase 9.6
cellulase 9.4
alpha-galactosidase 9.4
cellobiose phosphorylase 9.3
alpha-glucosidase 9.2
mannanase 9.2
hydroxyisourate hydrolase 9.2
azoreductase 9.1
phospho-beta-galactosidase 9.1
lactase-phlorizin hydrolase 9.1
phospho-beta-glucosidase 9.1
ent-kaurenoic acid oxidase 9.1
endo-beta-mannanase 9.1
N-acetylglucosamine kinase 9.0
beta-1,3-glucanase 8.9
beta-1,3-glucanase 8.9
alpha-glucuronidase 8.9
proteinase yscB 8.7
trehalase 8.7
xylanase 8.7
glucocerebrosidase 8.7
xylanase 8.6
lactase-phlorizin hydrolase 8.5
hydroxynitrile lyase 8.5
alpha-1,4-glucan lyase 8.5
alanine aminopeptidase 8.5
adenosine nucleosidase 8.4
hexosaminidase 8.4
alpha-N-acetylglucosaminidase 8.4
hydroxynitrile lyase 8.3
lichenase 8.3
beta-cyanoalanine synthase 8.3
hydroxynitrile lyase 8.3
beta-glucuronidase 8.1
lactase 8.0
nicotinamide adenine dinucleotide glycohydrolase 7.9
beta-galactosidase 7.9
glutamate-1-semialdehyde aminotransferase 7.8
prozyme 7.8
beta-amylase 7.8
isopentenyltransferase 7.7
glucosidase II 7.7
PelA 7.7
sucrase-isomaltase 7.6
arylsulfatase 7.6
dextranase 7.6
sucrase 7.5
acetylesterase 7.5
UDP-glucosyltransferase 7.5
glucoamylase 7.5
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Compound
Menisdaurin 13.2
Calystegin B2 13.2
Tuberonic acid glucoside 13.2
Terbacil 12.2
dolichyl beta-D-glucosyl phosphate 12.2
Calystegin A3 12.2
Australine 12.2
Raucaffricine 11.7
Casuarictin 11.7
Coniferin 11.5
Glucosylsphingosine 11.5
Gentiobiose 11.5
Vicine 11.4
3-methylbutanal oxime 11.2
1-deoxypentitol 11.2
alpha-Zearalenol 11.2
DIMBOA-glucoside 10.9
3-morpholinone 10.9
Nojirimycin 10.8
heptitol 10.8
heptitol 10.8
heptitol 10.8
4-methyl-1-pentanol 10.7
heptitol 10.6
nonanamide 10.4
Gluconolactone 10.3
3-Methyl-4-nitrophenol 10.2
Cellobiose 10.1
4-Phenylimidazole 10.1
Phenthoate 10.1
9H-xanthen-9-ol 9.8
Glucosylceramide 9.7
Amygdalin 9.7
Amygdalin 9.7
Dhurrin 9.7
1,9-nonanediol 9.7
Castanospermine 9.6
Cycasin 9.5
Strictosidine 9.5
1,7-heptanediol 9.5
F461 9.3
D-Fucose 9.3
CDP-glucose 9.3
DMDP 9.3
Lichenan 9.2
Sophorose 9.2
Woodward's Reagent K 9.1
Hydroxyatrazine 9.1
Methylazoxymethanol acetate 9.1
NPG 9.0
Coniferaldehyde 8.9
2-amino-2-(hydroxymethyl)-1,3-propanediol 8.9
2-amino-2-(hydroxymethyl)-1,3-propanediol 8.9
2-amino-2-(hydroxymethyl)-1,3-propanediol 8.9
3-Hydroxykynurenine 8.8
Esculin 8.8
selenic acid 8.8
selenic acid 8.8
selenic acid 8.8
DIMBOA 8.8
beta-D-galactoside 8.6
C6H12O6 8.5
Esculin 8.5
Veratryl alcohol 8.4
Veratryl alcohol 8.3
Laetrile 8.2
PC-2 8.2
Validamycin A 8.1
Sinigrin 8.0
ReSe2 8.0
3-Hydroxykynurenine 7.9
Aucubin 7.9
Salicin 7.8
Salicin 7.8
GDP-glucose 7.8
Isoflavone 7.7
Maltotriose 7.6
Oleuropein 7.6
IBT 7.5
gamma-CEHC 7.5
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