Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.2.1.21 (beta-glucosidase)
 3,280 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In order to investigate the hypothesis that the glycosidase inhibitor isofagomine was bound to alpha- or beta-glucosidase in a 1,4B conformation, a number of bicyclic aziridines that adopt the 1,4B or B1,4 conformations were synthesised and investigated. (1R)-2-endo,3-exo-2,3-Dihydroxy-4-endo-4-hydroxymethyl-6- azabicyclo[3.1.0]hexane (5) and its N-methyl and N-benzyl analogues and (1S)-2-exo-3-endo-2,3-dihydroxy-4- endo-4-hydroxymethyl-6-azabicyclo-[3.1.0]hexane (6) were synthesised. The aziridines 5 and 6 were found to be weak or not inhibitors of alpha-glucosidase, beta-glucosidase and alpha-fucosidase.
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PMID:Aziridines as a structural motif to conformational restriction of azasugars. 1292 48

In this era, major community worldwide is suffering from diabetes type II, cancer and neurodegenerative disorders. To overcome these diseases, in the screening of Korean medicinal plants, we studied the whole plant of Boehmeria nivea (B. nivea). The methanolic leaf, stem and root extracts of B. nivea and their respective n-hexane, methylene chloride (CH(2)Cl(2)), ethyl acetate (EtOAc), n-butanol (BuOH) and aqueous fractions were investigated for their total phenolic content (TPC), 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity, alpha-glucosidase, beta-glucosidase, alpha-galactosidase, beta-galactosidase, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzyme inhibition activities. Profound TPC and DPPH free radical scavenging activities were observed in the EtOAc and BuOH fractions of root, where the BuOH fraction showed high-pitched alpha-glucosidase inhibition and the EtOAc layer showed the maximum beta-glucosidase inhibition. Furthermore, the leaf extract demonstrated the highest beta-galactosidase inhibitory activity, but no alpha-galactosidase inhibition was seen in any of the plant parts. Notable BChE and moderate AChE inhibitory activity was found in whole plant. It can be suggested that whole plant of B. nivea provides a strong biochemical rationale as one of the good choices for the treatment of diabetes type II, cancer and neurodegenerative diseases (AD, etc).
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PMID:Evaluation of antiglycosidase and anticholinesterase activities of Boehmeria nivea. 2036 6

A quantitive method for the determination of imidocarb residue in edible tissues of swine by high performance liquid chromatography (HPLC) was developed. The analyte was digested by beta-glucosidase first, and then extracted with 1 mol/L hydrochloric acid. The aqueous phase was back-extracted with the mixture of hexane-isoamyl alcohol (3: 2, v/v) for the purification. The mobile phases were acetonitrile (phase A) and 0.007 5 mol/L 1-pentansulfonic acid sodium aqueous solution containing 0.1% triethylamine, adjusted to pH 3.0 with glacial acetic acid (phase B). The analyte was detected by ultraviolet absorption spectroscopy after the separation was achieved on a C18 RP column. The linear range was 10 - 10 000 micog/L, and the correlation coefficient was more than 0.999. The limit of detection (LOD) was 10 microg/kg, and the limit of qualification (LOQ) was 20 microg/kg. The mean recoveries of imidocarb in swine tissues at the added levels of LOQ, MRL (maximum residue limit) and 2MRL ranged from 80.04% to 110.32%, and the relative standard deviations (RSDs) of intra- and inter-day analyses ranged from 0.82% to 10.00%. The method is simple and sensitive for the quantification of imidocarb residue in swine tissues.
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PMID:[Determination of imidocarb residue in swine tissues by high performance liquid chromatography]. 2212 38