Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.20 (
alpha-glucosidase
)
4,237
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Diabetes mellitus is a most serious and chronic disease whose incidence rates are increasing with incidences of obesity and aging of the general population over the world. One therapeutic approach for decreasing postprandial hyperglycemia is to retard absorption of glucose by inhibition of
alpha-glucosidase
. Two bromophenols,
2,4,6-tribromophenol
and 2,4-dibromophenol, were purified from the red alga Grateloupia elliptica. IC(50) values of
2,4,6-tribromophenol
and 2,4-dibromophenol were 60.3 and 110.4 microM against Saccharomyces cerevisiae
alpha-glucosidase
, and 130.3 and 230.3 microM against Bacillus stearothermophilus
alpha-glucosidase
, respectively. In addition, both mildly inhibited rat-intestinal sucrase (IC(50) of 4.2 and 3.6mM) and rat-intestinal
maltase
(IC(50) of 5.0 and 4.8mM). Therefore, bromophenols of G. elliptica have potential as natural nutraceuticals to prevent diabetes mellitus because of their high
alpha-glucosidase
inhibitory activity.
...
PMID:Potent alpha-glucosidase inhibitors purified from the red alga Grateloupia elliptica. 1895 91
