Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.20 (
alpha-glucosidase
)
4,237
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Twenty-one naturally occurring flavonoids were tested for inhibitory activities against
alpha-glucosidase
(
EC 3.2.1.20
) and alpha-amylase (EC 3.2.1.1).
Luteolin
, amentoflavone, luteolin 7-O-glucoside, and daidzein were the strongest inhibitors among the compounds tested.
Luteolin
inhibited
alpha-glucosidase
by 36% at the concentration of 0.5 mg/ml and was stronger than acarbose, the most widely prescribed drug, in inhibitory potency, suggesting that it has the possibility to effectively suppress postprandial hyperglycemia in patients with non-insulin dependent diabetes mellitus.
Luteolin
also inhibited alpha-amylase effectively although it was less potent than acarbose. The clinical value of luteolin needs to be further evaluated.
...
PMID:Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid. 1119 16
