Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.20 (
alpha-glucosidase
)
4,237
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Cowper's glands of rats were analysed for ten different biochemical parameters including enzymes and substrates under different hormonal status of the animals.
Sialic acid
, glycogen and activities of
maltase
and alkaline phosphatase enzymes of the prepuberal glands were found to be elevated to the levels of the adult (control animals) after treatment with testosterone propionate. On the other hand, following castration of adult animals a dramatic fall of the
maltase
activity of the gland was recorded; other parameters studied also registered a significant fall from their normal values. However, following treatment with testosterone propionate of the castrate animals all parameters excepting total lipids and phospholipids were found to recover.
Sialic acid
of the prepuberal animals and
maltase
activity of the adult were highly sensitive to testosterone propionate.
...
PMID:Biochemical Composition of rat Cowper's gland. 702 9
Terminal glycomoieties of varicella-zoster virus glycoproteins were characterized by their reactivity with lectins and glycosidases, and the functional roles of terminal sugars were analyzed by cell-free virus infectivity. Terminal glycan structures of gpl possessed sialic acid linked alpha (2-3) to galactose of O-linked glycan and galactose-beta (1-4)-N-acetylglucosamine of N-linked glycan. Those of the putative gpIV possessed galactose-beta (1-4)-N-acetylglucosamine of N-linked glycan. Both glycoproteins had mannose alpha (1-3, 6, or 2) linked to mannose in their glycans. Their biological functions on cell-free virus infectivity were assessed by using lectins and exoglycosidases.
Sialic acid
of glycans on both the viral envelope and the cell surface had a negative effect on infectivity, and the latter had a larger effect on infectivity than the former. Maackia amurensis agglutinin, which recognizes sialic acid, enhanced infectivity more than expected from the simple neutralization of the negative effects of sialic acids between cells and virus. alpha-Mannosidase and
alpha-glucosidase
treatments of virus significantly reduced infectivity but those of cells did not. Therefore, alpha-mannose and alpha-glucose residues on the viral envelope had functional roles in cell-free virus infection. Inactivation of virus infectivity by concanavalin A was mainly due to the blocking of functional roles of terminal alpha-mannose and alpha-glucose residues of viral glycoproteins.
...
PMID:Functional roles of terminal glycomoieties in varicella-zoster virus infection. 825 82
