Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.20 (alpha-glucosidase)
 4,237 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In vivo injection, into emerging bees, of a quantity of trehalose sufficient to double the initial natural haemolymph level of the sugar, leads first to a reduction in the maximal velocity (Vm) of the alpha-glucosidase activity, after 2 hours, followed by an increase in Vm at 6 hours, then a return to normal. The substrate constant (KR) shows minor and insignificant fluctuations about the initial value, and the Hill coefficient (h) a slight, but significant, rise 2 h and 8 h after injection. The simultaneous injection of a protein synthesis inhibitor (ISP) reduces the changes in Vm and h, and lowers value of the ratio Vm/KR from 6 h to 16 h after injection. The overall pattern of results prompts the hypothesis of an intermediary ISP-sensitive induction of an inhibitor of the enzyme-substrate complex, preceding the phase of induction or liberation of active enzyme molecules whose aggregation is subject to a succession of rearrangements alternately favourable to sucrose (lesser specificity) or to trehalose (heightened specificity).
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PMID:[Kinetic study of mixed alpha glucosidase activity induced in honeybee hemolymph by in vivo injection of trehalose]. 180 94

Streptomyces sp. TM-521 which produced alpha-glucoside hydrolase inhibitors, adiposins, was isolated from a soil sample collected in Hoya City, Tokyo. The strain belonged to the "gray color" series type of the ISP-classified Streptomyces. From the taxonomic studies, the strain TM-521 resembled with Streptomyces calvus in the morphological and physiological properties. This strain was accordingly identified as a strain of Streptomyces calvus.
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PMID:Studies on the alpha-glucoside hydrolase inhibitor, adiposin. II. Taxonomic studies on the producing microorganism. 714 21