Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.20 (
alpha-glucosidase
)
4,237
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Previous studies have indicated that
alpha-D-glucosidase
activity is increased and exhibits abnormal properties in tissues from patients with cystic fibrosis (CF). In the present investigation serum
alpha-D-glucosidase
from patients with CF and from patients with chronic pulmonary disease (e.g. asthma and
bronchiectasis
) has been studied to determine the specificity of the
alpha-D-glucosidase
alteration(s) in CF sera. Both groups of patients have elevated
alpha-D-glucosidase
activity levels and similarly abnormal isoelectric focusing profiles with significantly less activity associated with acidic enzymatic forms (i.e. having isoelectric points below 4.8). These results suggest that the abnormalities of CF serum
alpha-D-glucosidase
may be secondary to chronic pulmonary disease and emphasize the importance of including appropriate pathological controls in biochemical studies on CF.
...
PMID:Serum neutral alpha-D-glucosidase from patients with cystic fibrosis and chronic pulmonary disease. 388 49
