Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.2.1.17 (lysozyme)
 21,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Immunostimulants are widely used in aquaculture, but there are few reports on the genes that are expressed by their stimulation. Therefore, in this study, expressed genes in the kidney of Japanese flounder Paralichthys olivaceus injected with the immunostimulant peptidoglycan were analysed. The results of single-pass sequencing of ESTs from 198 clones (AU090255-AU090451, AU090935) from kidney cDNA are presented. Sequences of the cDNA clones were compared with sequences in the GenBank database. One hundred and six clones (53.5%) appeared to be completely unknown and are likely to represent newly described genes, whereas 92 clones (46.5%) were identified based on matches to sequences in the database. The results contain the genes such as alpha globin (AU090287), several ribosomal proteins (AU090-263, 274, 299, 351, 365, 375, 377, 382, 434, 445), heat shock protein 90 (AU090374) and cytochrome oxidase subunit (AU090385). Immune related cDNAs identified from the kidney were immunoglobulin heavy (AU090291) and light chain (AU090352), beta2-microglobulin (AU090280), macrophage inflammatory protein 1-alpha precursor (AU090535), thymosin beta-10 (AU090391), lysozyme (AU090322) and MHC class IIalpha (AU090435). It is possible that expression of macrophage inflammatory protein 1-alpha results in macrophage activation as a consequence of peptidoglycan treatment.
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PMID:The analysis of expressed genes in the kidney of Japanese flounder, Paralichthys olivaceus, injected with the immunostimulant peptidoglycan. 1141 22

Gastric carcinoma is the fourth most common cause of cancer death worldwide but its molecular biology is poorly understood. We catalogued the genes expressed in two gastric adenocarcinomas and normal stomach, using serial analysis of gene expression (SAGE), and compared the profiles on-line with other glandular epithelia. Candidates were validated by Northern blotting and immunohistochemistry. A total of 29 480 transcripts, derived from 10 866 genes, were identified. In all, 1% of the genes were differentially expressed (>/=fivefold difference plus P-value </=0.01) between cancers and normal stomach. The most abundant transcripts included ribosomal and mitochondrial proteins, of which most were upregulated in the tumours, as were other widely expressed genes including transcription factors, signalling molecules (serine/threonine protein kinases), thymosin beta 10 and collagenase I. Transcripts abundant in normal stomach were functionally important, including gastrin, immunoglobulin alpha, lysozyme, MUC5, pS2 and pepsinogens, which were among 55 gastric-specific genes. Many transcripts were minimally characterized or new, some cancer-associated genes reflected their intestinal morphology, and some normal gastric genes had previously been considered as pancreatic carcinoma markers. The gastric carcinoma profiles resembled other tumours', supporting the existence of common cancer-associated targets. These data provide a catalogue from which to develop markers for better diagnosis and therapy of gastric carcinoma.
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PMID:Profiling, comparison and validation of gene expression in gastric carcinoma and normal stomach. 1283 51