Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.2.1.17 (lysozyme)
 21,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

One hundred and twenty-two cases of midline malignant reticulosis (MMR) were studied. A series of antibodies including anti-LCA, UCHL-1, L26, CD45R, and anti-lysozyme were used on paraffin sections by ABC and PAP methods. The results were as follows: 112 cases exhibiting T-cell origin, 4 cases showing B-cell origin, and 6 cases being of uncertain lineage. This result is in accordance with the point of view that most of MMR are T cell lymphoma. Two histological types were classified: sarcomatoid type and granulomatoid type. By using image analyzer, the sarcomatoid type was subdivided into small, medium and large cell types. Sixty-two cases with follow-up data were collected for clinicopathologic analysis. One-year and five-year survival rates in cases with different histologic types were compared and statistically analysed. The results showed that the prognosis was closely related to the histological type.
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PMID:[A clinicopathological immunohistochemical and cytomorphometric study on midline T cell lymphoma]. 986 56

Two horses with Rhodococcus equi infection were examined post mortem by an immunohistochemical method (peroxidase-antiperoxidase; PAP) with a monoclonal antibody (Mab 10G5) to the 15-17 kDa antigen of R. equi. One of the horses was also examined bacteriologically, R. equi being isolated in culture. Immunolabelling with this Mab was marked and widespread. On the other hand, the immunohistochemical reactivity of infected macrophages with a polyclonal antibody specific for lysozyme was slight. Thus, Mab 10G5 would appear to be a useful diagnostic reagent in R. equi infection, with or without cultural confirmation.
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PMID:Immunohistochemical detection of virulence-associated Rhodococcus equi antigens in pulmonary and intestinal lesions in horses. 1103 73


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