Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.17 (
lysozyme
)
21,489
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Antisera to
aldehyde reductase
from fruit-fly (Drosophila melanogaster) and chicken were cross-reacted with
aldehyde reductase
from several species of insects and birds using the technique of microcomplement fixation. Large differences in immunological distances are evident between species of the Class Insecta and of the Class Aves indicating considerable differences in the amino acid sequences of the
aldehyde reductase
of these species. Immunological distances for
aldehyde reductase
between pairs of insect species or bird species when plotted against the immunological distances for transferrin, albumin,
lysozyme
and alpha-glycerophosphate dehydrogenase for the same pairs of species gave a linear relationship in each case. From these relationships the rate of evolution of
aldehyde reductase
in terms of a unit evolutionary period (UEP) was calculated to be 12 which agreed favorably with the value previously obtained from compositional comparisons. A UEP of 12 is approximately half that of lactate dehydrogenase and shows that
aldehyde reductase
is evolving at twice the rate of glycolytic enzymes. This may indicate a relatively non-essential metabolism role for the enzyme.
...
PMID:Evolution of aldehyde reductase: an immunological approach to the relatedness of aldehyde reductase from different species. 677 12
