Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.17 (
lysozyme
)
21,489
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Doxycycline
inhibited the release of
lysozyme
from human granulocytes and monocytes exposed to non-opsonized zymosan particles. This effect was more marked for granulocytes than for monocytes. Oxytetracycline, however, did not influence the release. The difference between the drugs can be explained by differences in their lipid solubilities. The divalent cation chelator, EDTA, also reduced the release of
lysozyme
from leukocytes exposed to non-opsonized zymosan. Accordingly, the selective release of
lysozyme
from human leukocytes is divalent cation dependent. The inhibition of release by doxycycline is most likely also due to binding of these ions. When the cells were exposed to UVA light in the presence of doxycycline, the inhibition of
lysozyme
release was potentiated. Using irradiated cells, maximal inhibition was obtained at 20 micrograms doxycycline/ml. However, it is not clear whether these results have clinical relevance.
...
PMID:Influence of tetracyclines and light on the release of lysozyme from human granulocytes and monocytes. 380 32
