Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.17 (lysozyme)
 21,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Prospects for the correction of disturbances in the macrophagal system with a combination of lysozyme and vitamin E in patients with a protracted course of dysentery caused by Shigella flexneri 1b were studied. The phagocytic activity of macrophages (PAM) was found to be suppressed as early as at the beginning of the disease. Out of 38 persons repeatedly found to release shigellae 24 were administered polychemotherapy. PAM indices in patients treated with lysozyme and tocopherol acetate were likely to normalize, this being indicative of the positive effect of these preparations on the functional activity of the macrophagal system.
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PMID:[The clinical assessment of macrophage functional activity in patients with protracted dysentery and its correction with lysozyme and vitamin E]. 130 66

Thirty-six 7-mo-old gilts were used to study the effects of dietary vitamin E and fat source (5% sunflower oil or animal fat) in pregnant and lactating sow diets on serum vitamin E concentration and on cell-mediated and humoral immune response in suckling and weaned piglets. Six gilts each received one of six diets throughout pregnancy and lactation. The basal diets (13 mg alpha-tocopherol/kg diet) were supplemented with dl-alpha-tocopheryl acetate to 48 and 136 mg alpha-tocopherol/kg of feed (average analyzed values). After weaning (at 4 wk of age) all pigs received identical diets (20 mg of alpha-tocopherol/kg feed). One week after weaning, pigs were immunized (i.m. with ovalbumin and tetanus toxoid) and antibody production was measured. Blood samples were taken immediately after birth, at 1 wk after birth, at weaning, and at four weekly intervals after weaning. Samples were analyzed for alpha-tocopherol concentration, total number of leukocytes, T- and B-lymphocytes, lymphocyte stimulation with concanavalin A, lysozyme activity, and immunoglobulin concentrations. It was concluded that a high vitamin E level in the sow's diet increased serum vitamin E concentration of 1-wk-old pigs (P less than .05). Immune response against ovalbumin was increased (P less than .05) at 1 wk of age after immunization for weaned pigs from sows fed the high level of vitamin E. Also, the phagocytic measures of pigs at 1 wk of age were increased by the medium vitamin E level (P less than .05). Fat sources in the sow's diet had no consistent effect on the immunological measures of pigs.
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PMID:Effect of vitamin E and fat source in sows' diets on immune response of suckling and weaned piglets. 190 58

1. The sequence of renal cellular membrane damage induced by gentamicin was studied in the rat by using the release of alkaline phosphatase, acid phosphatase, muramidase and protein from renal cells as indices of renal damage. 2. The protective effect of a combination of vitamin E and selenium against renal damage was also investigated. 3. Gentamicin (60 mg kg-1 body weight) was nephrotoxic within 12 h of the first dose. 4. The plasma membrane of the renal tubules is damaged before the lysosomal membrane is affected. 5. A combination of vitamin E (1 mg g-1 body weight) and selenium (4 x 10(-3) mg g-1 body weight) attenuates the renal damage induced by gentamicin. Results suggest synergism between vitamin E and selenium in attenuating the renal damage. The possible mechanism of attenuation is discussed. 6. Vitamin E and selenium may have anti-diuretic potential.
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PMID:Vitamin E and selenium in gentamicin nephrotoxicity. 226 Dec 41

Lymphoproliferative responses to phytohaemagglutinin and other phytolectins declined following prolonged exposure of lambs to a diet deficient in both selenium and vitamin E, coinciding with the development of nutritional myopathy. Supplementation restored lymphocyte responses within a week and led to a rapid decline in circulating activity of the muscle enzyme creatine kinase in serum. Lymphocyte responses of the dams remained largely unaltered throughout the experiment. There was no evidence of erythrocyte damage in myopathic lambs, concentrations of serum IgG, IgM and lysozyme were similar to those in healthy lambs, and chemiluminescence tests on whole blood samples failed to reveal a phagocytic defect in response to particulate and non-particulate stimuli. However, serum from myopathic lambs did show a reduced opsonic capacity.
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PMID:Immunological malfunctions associated with low selenium-vitamin E diets in lambs. 231

Influence of supplemental Se on humoral immune response was measured in 60 weaned beef calves with marginal blood Se status. Calves were fed a Se-deficient diet consisting of corn silage, corn grain, and soybean meal. Blood Se concentrations, primary and secondary humoral immune responses to hen egg lysozyme inoculation, and weight gain were determined in a 70-day trial. Calves fed 20 mg of Se/kg of mineral mixture ad libitum had lower antibody responses (P less than 0.02), compared with calves fed 20 mg of Se/kg of mineral mixture and given 0.1 mg of Se and 0.22 IU of vitamin E/kg of body weight, IM, or with calves fed 80, 120, 160, or 200 mg of Se/kg of mineral mixture. Calves fed 80, 120, 160, or 200 mg of Se/kg of mineral mixture had higher (P less than 0.001) blood Se concentrations on day 70, compared with calves fed 20 mg of Se/kg of mineral mixture and given 0.1 mg of Se and 0.22 IU of vitamin E/kg of body weight, IM. Selenium supplementation had no effect on weight gain.
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PMID:Influence of supplemental selenium on humoral immune responses in weaned beef calves. 280 10

Hen eggs were used for the preparation of a multicomponent additive to milk mixtures for infants. Lysozyme hydrolysate containing up to 1 mg/ml lysozyme was obtained from egg albumen according to a specially developed technology. The hydrolysate was supplemented with vitamins C and PP. The egg yolk was used for the preparation of a yolk-fatty emulsion enriched with vitamin E, copper sulfate and ferrous lactate. Characteristics of the cow milk and milk mixtures supplemented with the multicomponent additive are maximally close to those of the human milk. The clinical trials of the lactic acid mixtures enriched with the multicomponent additive showed their high effectiveness in the nutrition of normal and sick infants. The technology of the additive production is simple; it is inexpensive and can be easily transported.
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PMID:[A multicomponent additive intended for preparing infant milk mixtures enriched with essential and protective factors]. 373 16

It has been shown in experiments on mice, guinea-pigs and rabbits that additional administration to the animals of vitamin E provokes an increase in the content of T lymphocytes in the peripheral blood without exerting any effect on the content of B lymphocytes. Such an addition also markedly stimulates natural killers of spleen lymphocytes. The complementary, lysozyme and nonspecific bactericidal activity of blood serum remains unchanged in this case.
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PMID:[Effect of vitamin E on T and B lymphocyte numbers in the peripheral blood and various indicators of nonspecific immunity]. 633 6

Free radicals derived from one-electron oxidation of the amino acids tryptophan, tyrosine, methionine and histidine have been found to be rapidly (k = 10(7) -10(9) dm3 mol-1 s-1) and efficiently repaired by Trolox C, a vitamin E analogue. The reactions form a relatively stable phenoxyl radical of Trolox C (lambda max = 440 nm; epsilon = 5.4 X 10(3) mol dm-3 cm-1). The radical cation of tryptophan is more rapidly repaired than the neutral tryptophan radical. Repair of tryptophanyl radicals in the enzyme lysozyme has also been observed. The results suggest that a function of alpha-tocopherol in membranes may be the repair of radicals of integral membrane proteins.
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PMID:Repair of amino acid radicals by a vitamin E analogue. 670 21

This study evaluated the effect of a single exposure to sulfuric acid aerosol on six human biochemical blood parameters. A total of 18 human subjects were exposed to ambient air for 4 hr on the first day of exposure and to 100 microgram/m3 (0.033 microM) sulfuric acid aerosol (0.5 micrometer mean mass diameter) for 4 hr on the second day. A total of 17 human subjects were exposed for 4 hr to ambient air on both exposure days. On each exposure day, at 30 min and 90 min after exposure was initiated, all subjects engaged in a 15-min exercise period (walking 4 mph on a treadmill inclined at 10 degrees). Six biochemical blood parameters were measured before and after exposure: glutathione, lysozyme, glutathione reductase, serum glutamic oxaloacetic acid transaminase, serum vitamin E, and 2, 3-diphosphoglyceric acid. The results indicate no significant effect of one 4-hr exposure of humns to 100 microgram/m3 sulfuric acid aerosol. One significant post-exposure effect did occur--an increase in glutathione reductase--for both the control and acid-exposed group. It is concluded that at the levels studied, sulfuric acid aerosol is neutralized in the upper airways; consequently, no cellular damage is measurable.
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PMID:Biochemical changes in humans upon exposure to sulfuric acid aerosol and exercise. 742 76

This study evaluated the effect of sulfuric acid aerosol exposure for 2 consecutive days on seven human biochemical blood parameters. A total of 20 human subjects were exposed to 100 micrograms/m3 (0.033 microM) sulfuric acid aerosol (0.5 microns mean mass diameter) for 4 hr/day for 2 consecutive days. A total of 17 human subjects were exposed to 4 hr of ambient air on both exposure days. The chemical blood parameters were measured pre- and post-exposure, and 20 hr after the second exposure: serum glutathione, red blood cell glutathione reductase, red blood cell glucose-6-phosphate dehydrogenase, lysozyme, serum glutamic oxaloacetic acid transaminase, serum vitamin E, and 2, 3-diphosphoglycerate. The results indicate no significant response in any of the seven biochemical blood parameters measured. At this level, repeated exposure did not over-burden the upper airway defenses against acid aerosol.
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PMID:Biochemical effects of sulfuric acid mist inhalation by human subjects while at rest. 744 96


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