Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.2.1.17 (lysozyme)
 21,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of primary splenic angiosarcoma with involvement of two accessory spleens is presented. The tumor cells are immunoreactive for endothelial markers (CD 31, CD 34, factor VIII associated antigen) and express also histiocytic antigens (CD 68, lysozyme, Cat-hepsin D, alpha-1-antitrypsin, alpha-1-anti-chymotrypsin) as well as CD 8. This marker profile suggests that the presented angio-sarcoma originates from sinus cells with histiocytic and endothelial differentiation and may be regarded as the malignant variant of littoral cells angioma.
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PMID:[Littoral cell angiosarcoma of the spleen. Morphologic, immunohistochemical findings and consideration of histogenesis of a rare splenic tumor]. 943 77