Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.17 (lysozyme)
 21,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

800 malignant (22.9% Hodgkin's, 77.1% non-Hodgkin's) lymphomas, 22 cases of lymphogranulomatosis X and 16 pseudolymphomas were investigated by histology and immunomorphology. Age- and sex-distribution, localization as well as intracytoplasmic immunoglobulins (Ig) in tumour cells were evaluated. Hodgkin's lymphomas were classified according to Lukes (1971), the non-Hodgkin's lymphomas (NHL) according to the Kiel-classification. Among NHL of low grade malignancy the most common type was chronic lymphocytic leukaemia (CLL) (18%), among the NHL of high grade malignancy the immunoblastic lymphomas (IB) (13%). In IB 5 cases of T-cell type of IB were be identified. 8 cases were classified as "histiocytic" reticulosarcomas. Immunomorphology performed on routinely formalin-fixed, paraffin-embedded tissue sections showed a clear-cut difference between CLL and immunocytic lymphomas (IC): In all IC "monoclonal" Ig could be detected in lymphoplasmacytoid and plasma cells. The most common Ig was of the IgM/K type. 4 IC were turned out as "biclonal" ML detected by the double immunofluorescence. In IB lymphomas less than 50% contained intracytoplasmic Ig mainly of the IgM/K type. In Hodgkin's- and Sternberg cells sometimes IgG, K, lambda and also lysozyme was observed intracytoplasmically. This finding supports the hypothesis of the macrophage origin of these cells. In lymphogranulomatosis X and in lymphoepithelioid cell lymphoma (Lennert's lymphoma) as well as in pseudolymphomas "polyclonal" Ig containing "reactive" plasma cells was demonstrable. Immunomorphology on routine pathological material is able to facilitate differential diagnosis of ML and to elucidate to some extent derivation of ML.
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PMID:[Malignant and benign lymphomas: histologic classification and immunomorphologic studies. Results of 838 cases]. 698 28

A case of T cell-rich B cell lymphoma (TCRBCL) with Epstein-Barr virus (EBV) infection in tumor cells is reported. A 50 year old male developed right cervical lymph node swelling in July 1988. Initial biopsy in April 1989 demonstrated many scattered Hodgkinoid atypical cells with Lennert's lesion. After partial remission following chemotherapy, the lymph nodes enlarged again, and a second biopsy in February 1991 showed an IBL-T-like lesion. Only a small number of Hodgkinoid atypical cells were still observed. After apparently, complete remission, the lesion soon recurred and the patient died in November 1992. Immunohistochemically the Hodgkinoid cells were positive for L26, but negative for LN2, LN3, UCHL-1, MT1, lysozyme, Ber-H2 and Leu-M1. Reactivity for immunoglobulins showed false-positive because of polyclonal staining. IgH monoclonality was detected by the polymerase chain reaction method in the first biopsied specimen, and by Southern blotting in the second biopsied snap-frozen specimen. Monoclonal TCR beta rearrangement was not detected. The Hodgkinoid atypical cells were positive for EBV-encoding RNA by in situ hybridization, and LMP-1 by immunostaining. Occasionally, EBV-bearing immunoblastic, medium sized, or small lymphocytic cells were also observed. This case indicates the possibility that EBV is related to the pathogenesis of TCRBCL.
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PMID:T cell-rich B cell lymphoma bearing Epstein-Barr virus in tumor cells: a case of IBL-T-like lesion following Lennert's lesion. 758 39