Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.17 (
lysozyme
)
21,489
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Klebsiella pneumoniae is a common virulent causative agent for pneumonia. Lysozyme has previously been shown to play an important role in nonimmune host defense of the airways. This study was undertaken to assess the role of
lysozyme
M, the major isoform of
lysozyme
in mouse lung, in the killing of K. pneumoniae in
lysozyme
M(-/-) mice and transgenic mice with increased expression of
lysozyme
(
lysozyme
(tg) mice). The airways of
lysozyme
M(-/-) mice maintained in a pathogen-free facility were colonized by Lactobacilli, a component of the oropharyngeal flora. No lactobacilli were detected in the lungs of wild-type (WT) or
lysozyme
(tg) mice. Twenty-four hours after intratracheal infection with K. pneumoniae, bacterial killing was enhanced 9-fold in
lysozyme
(tg) mice compared with WT mice and 43-fold compared with
lysozyme
M(-/-) mice. In survival studies, no
lysozyme
M(-/-) mice survived beyond 72 hours after infection, whereas 75% of
lysozyme
(tg) (p < 0.01) and 25% of WT mice survived to 120 hours (p < 0.01).
Deficiency of lysozyme
M in the lungs increased susceptibility to K. pneumoniae infection, whereas increased expression of
lysozyme
conferred resistance to infection and enhanced survival.
...
PMID:Mouse lysozyme M is important in pulmonary host defense against Klebsiella pneumoniae infection. 1476 58
