Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.17 (lysozyme)
 21,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The data on the study of antilysozyme and anti-interferon properties of 375 Klebsiella strains are presented. The heterogeneity of strains with respect to their antilysozyme and anti-interferon activity is described. As revealed in this study, these properties occur more frequently and considerably to a greater extent in strains isolated from patients with Klebsiella infections and from carriers. Strains, incapable of inhibiting lysozyme and interferon or capable to digest them poorly, prevail among strains isolated from healthy persons. The data on the relationship between the level of the persistence factors of Klebsiella and the source of their isolation are presented.
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PMID:[The factors in Klebsiella persistence]. 753 26

Standard (hemogram, routine biochemical indices) and non-standard hematological parameters reflecting monocytic-macrophagal system (MMS) function and antioxidant defense were investigated in 140 subjects who had worked in radionuclide-contaminated zone after the Chernobyl accident. As shown by measurements of iron serum metabolism, lysozyme, total interferon, CIC, chemiluminescence of venous blood mononuclear leukocytes, MMS in 50% of them underwent negative changes in suppressed antioxidant defense. Standard hematological findings registered abnormalities only in 8-27% of the examinees.
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PMID:[Hematological dispensary care for the participants in the cleanup of the aftermath of the accident at the Chernobyl Atomic Electric Power Station]. 770 48

BCG infection of mice provides a convenient model to study natural and cellular immunity to mycobacteria and the mechanisms of granuloma formation and repair. We have used a range of macrophage (M phi) membrane molecules and secretory products to investigate resident M phi-pathogen interactions and T lymphocyte-dependent recruitment and activation of M phi in different tissues of immature, normal adult and gamma interferon deficient animals. In situ hybridization (ISH), RT-PCR and immunocytochemical analysis of M phi gene and product expression have been correlated with in vitro study of endocytic and secretory activity in which biogel polyacrylamide bead-elicited peritoneal M phi are exposed to Th1 and Th2 cytokines, LPS, BCG and other stimuli. The role of resident and newly recruited M phi responding to BCG in liver, spleen, lung and brain has been defined by means of antigen markers expressed by M phi (F4/80, 7/4, CR3, macrosialin, sialoadhesin and scavenger receptor) and/or T and B lymphoid cells (MHC Class II, CD4, CD8, B220). Heterogeneity in M phi secretory activity was revealed by ISH analysis of lysozyme, TNF-alpha, IL-1 IL-6 and MCP-1, by in vitro assay of NO and superoxide anion production, and by RT-PCR studies of Th1 (interferon gamma) and Th2 (IL-4, IL-13, IL-10) lymphokine mRNA in tissues. Our studies confirm the importance of interferon gamma as a critical mediator of host resistance to mycobacterial infection and raise intriguing questions in regard to T cell and M phi functional heterogeneity in distinct tissue microenvironments.
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PMID:BCG-induced granuloma formation in murine tissues. 771 50

Abnormalities of the immune response can be secondary to old age, to several pathologic conditions (i.e. diabetes mellitus, renal failure, solid and lymphohematologic neoplasias, leukopenia, malnutrition, autoimmune diseases, AIDS), to surgical stress or to burns, and to immunosuppressive therapies, both medical (corticosteroids, cytotoxic agents, antilymphocytic globulins) and surgical (splenectomy) as well as radiant (extensive radiotherapy). Old age can affect both humoral (reduced antibody synthesis) and cell-mediated (thymus involution, diminished ratio Th/Ts, depression of both delayed hypersensitivity reactions and cytotoxic activity of K cells) immune response. Hyponutrition, often observed in the elderly, adds a reduced production of secretory IgA, lysozyme and interferon, diminished complementary activity, phagocytosis defects, and vitamin deficits. Furthermore, in some chronic diseases we can observe reduced primary antibody response or depression of delayed hypersensitivity reactions (renal failure, neoplasias), changes in leukocyte functions (diabetes mellitus, leukemias and lymphomas) and, in particular in solid neoplasias, increased activity of Ts lymphocytes and the presence of circulating immunocomplexes. Changes in phagocytosis, opsonization and chemotaxis are typically seen in burns, whereas surgical stress can cause some inhibition of cell-mediated immunity. Finally, after splenectomy it is possible to observe an increased synthesis of IgA and IgG and, on the contrary, reduced production of IgM and properdin.
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PMID:[Pathogenetic mechanisms responsible for producing a secondary immunodeficiency state]. 786 Dec 9

By using a nonneuronal cell system, evidence has previously been provided that tetanus toxin (TT) intoxication occurs in macrophages, impairing their secretory activity as well as their antitumoral activity. In particular, both secreted and total lysozyme (LZM) activities are reduced by TT treatment, provided that GG2EE macrophages have been preexposed to gamma interferon (IFN-gamma). In an attempt to provide insight into the molecular mechanisms underlying this phenomenon, we focused our attention on the levels of LZM-specific transcripts. GG2EE macrophages preexposed to IFN-gamma exhibited augmented levels of LZM-specific mRNA. Such an effect was detected 1 h after removal of IFN-gamma, peaked at 3 h, and gradually decreased with time in culture. Exposure of IFN-gamma-pretreated GG2EE macrophages to TT resulted in the prevention of the IFN-gamma-mediated upregulation of LZM mRNA levels. The phenomenon was mediated by the holotoxin (> or = 1 micrograms/ml) and abrogated by preexposure of the macrophages to the C fragment of TT. Protein kinase C (PKC) and Ca(2+)-calmodulin-dependent PK were likely involved in the IFN-gamma-mediated upregulation of LZM mRNA levels and biological activity, as assessed by PK inhibitors. Furthermore, PK inhibitors mimicked TT in impairing LZM activity of GG2EE macrophages, thus suggesting that impairment of PKC and/or the Ca(2+)-calmodulin-dependent PK pathway(s) may be one of the events involved in TT intoxication of macrophages.
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PMID:Toxic effects of tetanus toxin on GG2EE macrophages: prevention of gamma interferon-mediated upregulation of lysozyme-specific mRNA levels. 835 83

The effect of acyclovir (ACV) treatment on selected functions of human blood-derived macrophages was examined. ACV was not cytotoxic when applied in a wide range of concentrations. Only minor effects on macrophage functions were observed when cells were treated with therapeutic concentrations of ACV:phagocytosis and the production of interferon and tumor necrosis factor were slightly enhanced, while the production of lysozyme was reduced, in a dose-dependent manner. Interferon production was also reduced in the presence of high concentrations of ACV.
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PMID:Effect of in vitro acyclovir treatment on selected functions of blood-derived macrophages. 850 90

Previously, we reported that secretory component (SC), lactoferrin (LF), and lysozyme (LY) levels were significantly lower in saliva from smokeless tobacco (ST) users than in saliva from control non-tobacco users. However, the levels of salivary immunoglobulin A were significantly higher, albeit with an altered attachment of SC, in ST users than in control subjects. SC, LF, and LY are synthesized by secretory epithelial cells at mucosal sites adjacent to lymphocyte regions. In the present report, HT-29 human epithelial cells, cultured with various concentrations of an ST aqueous extract or pure nicotine (0 to 1 mg/ml) or cotinine (0 to 5 mg/ml), exhibited significantly lower levels of cell-associated cell lysate (CL) and secreted culture supernatant (CS) SC, LF, and LY than cells cultured without ST components. Nicotine significantly decreased (P < or = 0.05) the synthesis of SC by 20 to 100%, LF by 20 to 60%, and LY by 5 to 75% of CL and CS control values. Studies also indicated significant decreases (P < or = 0.05) in SC, LF, and LY levels in both CL and CS of cells cultured with ST aqueous extract or cotinine. Total cell numbers and metabolic activity significantly decreased primarily when cells were incubated with higher concentrations of ST extract, nicotine, or cotinine. The addition of human recombinant interleukin-4 or gamma interferon diminished the effects ST had on HT-29 cell synthesis of SC, LF, and LY. Our data indicate that nicotine, cotinine, and ST have an adverse effect on synthesis and secretion of SC, LF, and LY. These effects were below ST concentrations found to be cytotoxic for secretory epithelial cells. Furthermore, addition of interleukin-4 or gamma interferon reduced the suppressive effect of ST on synthesis or secretion of SC, LF, or LY.
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PMID:Effect of nicotine on secretory component synthesis by secretory epithelial cells. 887 39

An analysis of results of treatment of 100 patients with postinjectional abscesses (PA) has shown their tendency to continuous inflammation in (23.9 +/- 5.4)% of the cases. Under condition of long duration of PA microorganisms of Staphylococcus aureus species have been isolated which possess 2-6 times greater capacity for inactivating the natural antiinfectious resistance factors: lysozyme, complement, immunoglobulins, bacterial component of the interferon. The inclusion of oxytocin preparation into the scheme of treatment which inhibits manifestations of antilysozymal activity of staphylococci allowed the frequency of prolonged unfavourable periods of PA to be reduced to 10.9%.
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PMID:[The connection between the duration of the course of postinjection abscesses and the biological characteristics of the causative microorganisms]. 916 56

Investigating a complex of biological characteristics, including the inactivating ability of some antiinfectious resistance agents (lysozyme, complement, immunoglobulins, the bactericide component of interferon) in 229 and 257 E. coli and S. aureus strains, respectively, isolated from various sources has revealed the phenotypical polymorphism in the populations of these microorganisms, whose degree and specific features may be characterized by the indices of biological diversity and by the spectra of dominant biological profiles. Interpopulational variability in the bacteria was found to be determined by the specific features of their colonized ecotopes and to reflect the level of their adaptation to their inhabitance. There is a view of the organizational structure of the bacterial species as a whole complex of discrete populations of microorganisms, which include representatives of phenotypically different clone lines that occupy the optimum and some marginal econiches whose relation is supported by migration processes.
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PMID:[Role of intraspecific phenotypic diversity in the ecology of escherichia coli and staphylococcus aureus]. 918 54

The paper outlines the results of studies dealt with the detection of risk factors and groups for enterobiasis, the efficiency of the treatment of children suffering from the disease with medamine, biologicals, and Normase. It is shown that risk factors may include an abnormal course of antenatality, minor developmental malformations (diastema, dystrophy, abnormalities of the eye, hand, foot, etc.), as well as early artificial feeding of babies (before they reach 3 months of life). Enterobiasis is found to have a negative influence on the physical, nervous, and mental development and suppression of non-specific immunity in children, which is suggested by the reduction in salivary lysozyme activity, which is lower than the normal level and on blood alpha-interferon production. There is strong evidence for the considerable immunosuppressive effects of enterobiasis on the formation of a postvaccinal immunity against measles. When given in a single course dose, medamine shows a 100% efficiency in the treatment of enterobiasis. Moreover, bificol, bifidumbacterin, and Normase may be useful to enhance the treatment efficiency and children's recovery from enterobiasis.
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PMID:[New approaches to the eradication of enterobiasis in children]. 918 91


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