Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.17 (lysozyme)
 21,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Bilateral hilar and mediastinal lymphadenopathy was observed in a 32-year-old man who had been engaged in asbestos spraying for 16 years. Lymph nodes obtained from Daniel's biopsy revealed tissue reaction compatible with sarcoidosis. On the other hand, a large number of asbestos particles were detected in the lung tissue from transbronchial lung biopsy and in bronchoalveolar lavage fluid, but no epithelioid granuloma was observed in the lung tissue. Various immunoserological findings such as PPD skin test, serum angiotensin converting enzyme activity, serum beta-glucuronidase and lysozyme level, serum antinuclear antibody, lymphocyte subset of blood and bronchoalveolar lavage fluid were inconsistent with sarcoidosis. However, lymph node enlargement and immunological abnormalities in this patient may be related to asbestos exposure and may not have occurred merely by chance.
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PMID:Sarcoid reaction observed in a worker with a history of asbestos exposure. 223 96

We report a case of latent cardiac sarcoidosis in reference to differential diagnosis from giant cell myocarditis. A 68-year-old woman succumbed to subarachnoid hemorrhage and acute myocardial infarction within a period of 3 days. Autopsy revealed white fibrotic lesions in the lateral wall of the left ventricle and interventricular septum of the heart in addition to acute myocardial infarction of the anterior wall. Histology showed fibrotic granulomatous lesions with infiltration of lymphocytes and epithelioid cells. Many multinucleated giant cells of Langhans and foreign body types were scattered among these lesions. There was no lesion in the bilateral hilar lymph nodes, but typical epithelioid granuloma was noticed in the lymph node of the carina, liver, and spleen. So we concluded that the heart lesion was a case of cardiac sarcoidosis. Striation could not be seen in the multinucleated giant cells of the cardiac sarcoid lesion, and, using light microscopy, it seemed to us that these cells had no relation to the cardiac muscles. However, by immunohistochemistry (PAP method) some giant cells tested positive for myoglobin, and others tested positive for lysozyme. The fact that giant cells are not always derived from the cardiac muscle can't be used, as a criterion for the diagnosis of cardiac sarcoidosis. Giant cells in the lung and lymph nodes tested positive only for lysozyme. Hence, using only cardiac histology, it is difficult to make a differential diagnosis between cardiac sarcoidosis and giant cell myocarditis, especially in cases where there is multiple organ involvement.
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PMID:[A case of latent cardiac sarcoidosis in reference to differential diagnosis from giant cell myocarditis]. 230 29

We report about two female patients with a histopathological proven granulomatous myositis associated with a fasciitis. One patient showed noncaseating granulomas in the muscle fascia. She suffered from symmetrical contractures of the digital flexors and ankles. The second patient showed uveitis and polyneuropathy, too. In addition, increased activities of the angiotensin-converting-enzyme and lysozyme in the sera suggested that both cases represent a new form of sarcoidosis.
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PMID:[Fasciitis in granulomatous myositis--an atypical manifestation of sarcoidosis?]. 233 6

The number and distribution of lysozyme and S100 immunoreactive cells were analyzed in ten cases of lymph node sarcoidosis. Three phases of granuloma development could be differentiated, each showing a typical immunohistological pattern. The early small granulomas consisted of lys- or very weakly lys+ mononuclear phagocytes and developed within an area of focalized accumulation of S100+ antigen-presenting cells. The mature large granulomas were composed of polygonal epithelioid cells with abundant cytoplasm showing very strong granular lysozyme positivity. S100+ cells could still be observed, mainly around the granulomas, but in diminished number. In the final fibrozing phase the epithelioid cells lost their lysozyme immunoreactivity and no S100+ antigen-presenting cells were present within or around the granulomas. In one patient granulomas with central necrosis and palisading, lys- epithelioid cells were also observed, possibly representing a different microenvironment (antigen/antibody equilibrium?). The change in the pattern and number of lysozyme and S100 immunoreactive cells probably reflects the development of the granulomas and is related to the activity of the disease.
Sarcoidosis 1987 Mar
PMID:The distribution of S100 and lysozyme immunoreactive cells in the various phases of granuloma development in sarcoidosis. 243 36

Immunohistochemically, the presence of lysozyme (LZ) has been detected by the antibody against human LZ in cytoplasm of cells from granulomatous and histiocyte-proliferative skin diseases. To detect LZ in these cells morphologically, I have done electron microscopic observations of the following skin diseases; sarcoidosis, lupus vulgaris, lupus miliaris disseminatus faciei (LMDF), tattoo granuloma, lichen nitidus, foreign body granuloma, granuloma annulare, xanthelasma, xanthoma tuberosum, xanthoma planum, juvenile xanthogranuloma, giant cell tumor of tendon sheath, dermatofibroma, malignant fibrous histiocytoma, dermatofibrosarcoma protuberans, granulation tissue of burn, hypertrophic scar, and histiocytosis X. From both the immunohistochemical and the electron microscopic features it was concluded that a) immunohistochemically LZ-positive cells from lesions of sarcoidosis, lupus vulgaris, LMDF and tattoo granuloma had a number of electron-lucent bodies (ELB) or microvesicles in their cytoplasm, b) lichen nitidus and xanthoma tuberosum had few LZ-positive cells and the ELB were not observed, and c) the other diseases were LZ-negative, and the ELB were also absent. It is suggested that LZ is present in the ELB which are observed electron microscopically.
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PMID:[Lysozyme-positive cells and ultrastructural findings in granulomatous and histiocyte-proliferative skin diseases]. 254 57

Due to the diagnosis difficulties posed by sarcoidosis, new metabolic or biological tests were suggested for replacing and/or confirming the histopathological examination: determination of the serous levels of the angiotensin-convertase (ACS), lysozyme and acid phosphatase. For establishing the ACS diagnosis value, the enzyme serous level was determined in 117 sarcoidosis patients, histopathologically confirmed (62 with active sarcoidosis, 55 with chronic sarcoidosis) in comparison with 109 patients suffering from other chronic lung affections. The results obtained, statistically processed, showed that the ACS level in active sarcoidosis is increased in 97% of the patients and only in 8% of the patients non-suffering from sarcoidosis. In active sarcoidosis, the ACS level has a positive predicting value of 86.8% and a negative one of 98%. The serous activities of lysozyme and acid phosphatase are not significant in sarcoidosis diagnosis. Of 59 treated patients with active sarcoidosis, in 58 the ACS value became normal after the clinical-radiological remission, thus showing the prognosis value of the test.
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PMID:[Serum enzyme tests in the diagnosis and follow-up of the evolution of sarcoidosis]. 255 62

A case of sarcoidosis presenting ataxic hemiparesis was reported. A 25-year-old man was admitted to Kanto Teishin Hospital because of slight weakness and dysesthesia in the right side of his body. His physical findings were normal. Neurological findings disclosed mild right hemiparesis (MMT 4+), cerebellar signs and mild dysesthesia in the same side. Laboratory findings were within normal limits except for elevated serum ACE and lysozyme. Chest roentgenogram showed bilateral hilar lymphadenopathy and TBLB disclosed sarcoid granuloma. Though brain CT, brain MRI and cerebral angiography were within normal limits, the neurological features were thought to be due to sarcoidosis. They disappeared along with the decrease of ACE and lysozyme. This is the first report of ataxic hemiparesis due to sarcoidosis, and it is interesting in that ataxic hemiparesis, which is one of signs of diseases in central nervous system, is the first manifest clinical feature of sarcoidosis.
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PMID:[A case of sarcoidosis presenting ataxic hemiparesis as an initial clinical manifestation]. 258 93

It was shown that the functional state of neutrophils and monocytes in the peripheral blood of patients with sarcoidosis lowered which was evident from their lower absorbing capacity, lower numbers of the EAC-rosette-forming cells and higher metabolic activity. Prior prednisolone therapy influenced the functional state of neutrophils: the cell ability to reduce NBT and the activity of acid phosphatase decreased while the lysozyme levels and absorption capacity increased. The functional state of monocytes was in general the same in the patients treated and untreated with the glucocorticoid.
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PMID:[The effect of hormonal therapy on the functioning of phagocytosing blood cells in patients with sarcoidosis]. 258 51

An immunological study was carried out of 51 patients with pulmonary sarcoidosis. Two groups of patients were singled out: receiving and not receiving glucocorticoid treatment (prednisolone: 0.3 mg/kg of body weight). It was found that patients with pulmonary sarcoidosis revealed changes of the functional state of neutrophils and monocytes of the peripheral blood manifested in a reduction of their absorptive capacity, number of rosette-forming cells, adhesiveness of neutrophils, increase of oxygen-dependent metabolism, production of lysozyme by neutrophils. Prednisolone treatment effected the state of neutrophils manifested in a reduced acid phosphatase activity; the production of lysozyme increased, the absorptive capacity normalized.
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PMID:[The effect of prednisolone on the functional status of phagocytic cells in the peripheral blood of patients with pulmonary sarcoidosis]. 277 46

We determined the serum angiotensin converting enzyme and lysozyme levels in 221 patients with uveitis and in 67 control subjects. Angiotensin converting enzyme and lysozyme levels were found to be age dependent. Of the 221 patients, 12 had sarcoidosis. In patients with uveitis who had an angiotensin converting enzyme level above 50 units/l (mean + 2 S.D.), the sensitivity of the test was 84%, the specificity was 95%, and the predictive value was 47%. In these same patients the sensitivity was 60% for a lysozyme level above 8 mg/l (mean + 2 S.D.), the specificity was 76%, and the predictive value was 12%.
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PMID:The predictive value of serum angiotensin converting enzyme and lysozyme levels in the diagnosis of ocular sarcoidosis. 282 Feb 30


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