Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.17 (lysozyme)
 21,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mutants of Escherichia coli K12, deficient in up to three major outer membrane proteins b, c and d have been constructed. Mutants that lack the lipopolysaccharide sugar heptose are deficient in protein b. All heptose-deficient strains are supersensitive to lysozyme, various antibiotics and detergents. They excrete the periplasmic enzyme ribonuclease I. Mutants deficient in proteins c and/or d have the same sensitivity towards these compounds as the parent strain. Cells of single, double and triple mutants are all rod-shaped. Electrophoretic analysis of cell envelope proteins indicates that in some mutants the protein deficiency is partially compensated for by increased amounts of one or two of the other major outer membrane proteins. Heptose-deficient strains have an increased amount of 2-keto-3-deoxyoctonate.
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PMID:Heptose-deficient mutants of Escherichia coli K12 deficient in up to three major outer membrane proteins. 78 63

Protein deficiency increases the susceptibility of the host to infection. Depressed phagocytic function, fall in non-specific protective substances of the serum, and poor immune response have all been recorded in the literature. The malnourished population exhibit recurrent ocular infections. The role of local defence mechanisms, principally lysozyme, is not known hitherto. In the present report, protein-deprived weaning Wistar rats showed a significant reduction in lysozyme against Staphylococcus aftermentas.
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PMID:Lacrimal lysozyme alterations in experimental protein deficiency. 724 88