Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.17 (lysozyme)
 21,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Lysozyme activity was measured in amniotic fluid samples from 90 pregnant women with gestational age ranging from 30 to 41 weeks. Twenty-nine samples were from high-risk subjects with different pathologies and signs of fetal distress. The control group consisted of 20 normal and 41 pathological pregnant women, whose disorders included Rh isoimmunization, diabetes, systemic arterial hypertension and pre-eclampsia without signs of fetal distress. Amniotic fluid lysozyme levels in normal controls were similar to those detected in abnormal pregnant women without signs of fetal distress (means = 156.0 vs 131.8 micrograms/ml for 34-37 weeks of gestation), with a tendency toward higher values as pregnancy progressed to term (means = 182.1 vs 155.4 micrograms/ml for 38-41 weeks of gestation). Lysozyme levels were significantly lower in high-risk pregnant women with signs of fetal distress, regardless of neonate birth weight, than in subjects showing no such signs (means = 40.3 and means = 25.4 micrograms/ml at 34-37 and 38-41 weeks of gestation, respectively). These data support the possibility of using amniotic fluid lysozyme activity levels as an indicator of fetal distress.
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PMID:Amniotic fluid lysozyme activity in fetal distress. 209 89

Amniotic fluid lysozyme content of 127 normal and 37 abnormal specimens obtained from women at various stages of gestation was measured in this study. Normal amniotic fluid lysozyme content increased gradually from the early stage of gestation to the late part of the 2nd trimester, and rapidly after 32 weeks gestation. These changes in amniotic fluid lysozyme content are similar to changes in amylase and creatinine content reported previously. However, high levels of lysozyme activity were exhibited in cases of diabetic pregnancy, premature rupture of membrane, and fetuses with digestive disorders. However, amniotic fluid lysozyme content was low in cases of fetuses with anencephaly. Lysozyme content in cases of Rh incompatibility and preeclampsia was considered to be in normal range. These results might indicate that the significance of lysozyme activity on amniotic fluid is considerably different than the significance of other parameters such as amylase and creatinine activity.
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PMID:Amniotic fluid lysozyme content in normal and abnormal pregnancy. 706 59