Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.17 (lysozyme)
 21,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The course of meningococcal infection and nonspecific and specific immunity in children subjected to different regimens of pathogenetic therapy were studied. It was shown that the clinico-immunological indices were more favourable in children treated with lasix as a diuretic agent. Recovery with defects was observed in 6.8 per cent of the children of this group, while in patients subjected to routine treatment the respective value amounted to 14.6 per cent. The use of lasix in combination with penicillin increased the efficacy of penicillin therapy and shortened the recovery period by 8.4 +/- 0.2 days as compared to that of routine treatment. No unfavourable effect of elevated penicillin concentrations on the lysozyme activity, blood bactericidal characteristics and composition of immunoglobulins A, M and G in the children was recorded.
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PMID:[Efficacy of penicillin therapy of meningococcal infection in children undergoing different regimes of pathogenetic therapy]. 665 Dec 66

Local and humoral immunity factors have been studied in 152 patients with different forms of meningococcal infection. The peculiar pattern of the time course of changes in these factors, depending on the clinical form of the disease, has been revealed. In the generalized form of infection changes in the immunological characteristics of the saliva and blood serum (lysozyme, secretory immunoglobulin, immunoglobulins of the main classes and specific antimeningococcal antibodies) have been shown to be more essential than in the localized form.
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PMID:[Changes in specific and nonspecific immunity factors in saliva and serum of patients with different clinical variants of meningococcal infection]. 718 Feb 69

The degree of the antilysozyme activity (ALA) of 430 Neisseria meningitidis strains isolated from 379 healthy carriers in 11 closed groups with different epidemiological situation and in 3 family foci was studied by the method of delayed antagonism. 87% of the strains exhibited ALA in a concentration of lysozyme between 1 and 10 micrograms per ml of the medium; about 11% of them were highly active, inactivating 20 and 25 micrograms of lysozyme per ml. ALA was shown to be the constant sign of carriership. The ALA of 39 strains isolated in cases of prolonged carriership (exceeding 2 weeks) was essentially higher than the ALA of 20 strains obtained in a single isolation. N. meningitidis strains of groups A, B and C, mostly responsible for the appearance of the generalized forms of diseases, were essentially less active than N. meningitidis strains of groups X, Y, Z, 29E, W-135, as well as strains not classified with any group. No correlation between ALA and the presence or absence of hyaluronidase was noted. Analysis of the data obtained in this study revealed that the ALA of N. meningitidis strains isolated in closed groups and families was not linked with the presence or absence of morbidity in the generalized forms of meningococcal infection and the spread of carriership in these groups, but reflected only differences in the serological picture of strains circulating there. The role of ALA in the formation of prolonged N. meningitidis carriership requires further study.
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PMID:[The antilysozyme activity of the meningococci isolated from bacterial carriers in closed collectives with different epidemiological situations]. 806 8