Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.2.1.17 (lysozyme)
 21,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An important role of Cs137 as a new ecological factor was shown by analyzing the works of 31 authors. This radioisotope may at present be deceted in the organisms of all the inhabitants of this planet. The migration of Cs137 along the chain lichen-deer-man leads to its accumulation in the organism of human subjects living in the Extreme North and utilizing venison in their diet. Although the high sensitivity of immunological reactions to various unfavourable environmental factors is well known, the materials on the effect of incorporated Cs137 on immunity are scanty, Experiments on animals have shown changes in factors of nonspecific immunity (phagocytic reaction of blood neutrophils, bactericidal activity, lysozyme and complement titres of blood serum) and specific immunity (formation of antiviral antibodies). The blood of animals injured by the isotope displays complete and incomplete autoantibodies. A dependance between the immunobiological changes and the dose absorbed by the organism was demonstrated. The entry of CS137 into the organism of the inhabitants of the Extreme North who use venison in their diet did not, with the absorbed dose equalling up to 50 Mrem per year, lead to changes in their immunological reactivity.
 ...
PMID:Effect of Cs137 on immunological reactivity (review of literature). 110 96

Immunohistochemically, the presence of lysozyme (LZ) has been detected by the antibody against human LZ in cytoplasm of cells from granulomatous and histiocyte-proliferative skin diseases. To detect LZ in these cells morphologically, I have done electron microscopic observations of the following skin diseases; sarcoidosis, lupus vulgaris, lupus miliaris disseminatus faciei (LMDF), tattoo granuloma, lichen nitidus, foreign body granuloma, granuloma annulare, xanthelasma, xanthoma tuberosum, xanthoma planum, juvenile xanthogranuloma, giant cell tumor of tendon sheath, dermatofibroma, malignant fibrous histiocytoma, dermatofibrosarcoma protuberans, granulation tissue of burn, hypertrophic scar, and histiocytosis X. From both the immunohistochemical and the electron microscopic features it was concluded that a) immunohistochemically LZ-positive cells from lesions of sarcoidosis, lupus vulgaris, LMDF and tattoo granuloma had a number of electron-lucent bodies (ELB) or microvesicles in their cytoplasm, b) lichen nitidus and xanthoma tuberosum had few LZ-positive cells and the ELB were not observed, and c) the other diseases were LZ-negative, and the ELB were also absent. It is suggested that LZ is present in the ELB which are observed electron microscopically.
 ...
PMID:[Lysozyme-positive cells and ultrastructural findings in granulomatous and histiocyte-proliferative skin diseases]. 254 57