Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.2.1.17 (lysozyme)
 21,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Four cases of lymphoma of the breast are described seen over a period of 2 years amongst 362 cases of breast carcinoma and one of carcinosarcoma. All four were diffuse non-Hodgkin's lymphomas, two of IgM-Kappa secreting follicle centre cell and two of histiocyte origin. Routine histological and enzyme histochemical methods were unhelpful but the application of a panel of antisera for the demonstration of immunoglobulin heavy and light chains, lysozyme, alpha-1-antitrypsin as well as carcinoembryonic antigen and epithelial membrane antigen, enabled a confident diagnosis to be made. Primary lymphoma of the breast may not be a rare disease and the possibility exists that it is misdiagnosed as anaplastic carcinoma as indeed two of these cases were on the initial biopsies. Correct diagnosis is essential so that appropriate treatment may be applied.
 ...
PMID:Primary lymphoma of the breast. 392 71

Pleuropulmonary blastoma (PPB) is a rare and highly aggressive tumor in children and is distinct from ordinary pulmonary blastoma or carcinosarcoma of the lung. This report describes the phenotypical characteristics of seven PPB tumors. The patients were five females and two males, all diagnosed in their third year of life. Five tumors were located within the pulmonary parenchyma, one in the mediastinum, and one involved both lung and mediastinum. Two children are alive and five have died of disease. Histologically, PPB showed a diffuse proliferation of undifferentiated blastemal cells with additional areas of chondroblastic foci (six tumors), storiform pattern (three tumors), alveolar pattern (one tumor), and lipoblastic differentiation (one tumor). Immunohistochemically, tumor cells were positive for vimentin in five of five tumors, histiocytic markers (A1AT and A1ACT, four of six cases; lysozyme, two of six; KP1, three of five) and myogenic markers (desmin, four of six; HHF35, five of six). S-100 was expressed in the chondroblastic areas (in three of four cases). Epithelial membrane antigen and cytokeratin were positive only in epithelial or mesothelial cells entrapped in the tumor. Ultrastructural examination demonstrated a similarity between the proliferating cells in PPB and those seen in malignant fibrous histiocytoma; that is, PPB tumor was mainly composed of a mixture of primitive, fibroblastic, myofibroblastic, histiocytoid, and fibrohistiocytoid cells. Also identified were cells with rhabdomyoblastic differentiation (two tumors) showing thick and thin filaments with Z-discs. In conclusion, PPB showed phenotypical diversity and was composed of MFH-type cells and cells with more specific mesenchymal differentiation.
 ...
PMID:Pleuropulmonary blastoma in childhood. A tumor of divergent differentiation. 768 3