Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.17 (lysozyme)
 21,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two inbred strains of rat (Donryu and Sprague-Dawley strains) were developed. The skin reactions of these strains immunized with M. tuberculosis, hen egg albumin (OVA) or hen egg lysozyme and challenged with the purified protein derivative (PPD) or each antigen were even and uniform. The Donryu strain showed a typical Arthus reaction with petechiae and edema and a negligible delayed skin reaction, whereas the Sprague-Dawley strain showed a poor Arthus reaction and a typical delayed skin reaction with central necrosis and induration. The Arthus reaction or delayed skin reaction could be passively transferred to recipient rats of each strain by immune sera or sensitized peritoneal exudate cells (PEC), respectively.
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PMID:Development of two inbred strains of rats and characteristics of their skin reactions. 14 Jun 79

The pharmacological properties of KP-136, an inhibitor of type I allergy, were studied in rat paw models. In four allergic responses, three of the immediate type and one delayed type, KP-136 (p.o.) produced potent inhibitions on the mast cell-mediated type I allergy (ID30: 1.0 mg/kg) and the neutrophil-infiltrated passive Arthus reaction (ID30: 1.6 mg/kg). In addition, KP-136 (10 mg/kg, 50 mg/kg, p.o.) inhibited the injury of bone tissues in rat adjuvant arthritis, confirming that it was effective on the allergic inflammation with tissue injury. Although KP-136 was a weak inhibitor of carrageenin-induced paw edema, prostaglandin synthesis and complement-mediated hemolysis, the compound inhibited the release of lysosomal enzymes such as lysozyme and beta-glucuronidase in the passive Arthus reaction, suggesting the blockage of inflammatory mediator release for its mode of action.
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PMID:[Effect of KP-136 on allergic paw edema in the rat]. 214 18

Pulmonary alveolar macrophages (PAM) are present during acute lung inflammation, yet the functional role of these cells in both the initiation and resolution of lung injury is not well defined. To better understand the relationship between PAM functional responses and the evolution of acute reversible lung injury, we examined the ability of both unstimulated and stimulated (PMA, zymosan) PAM to secrete reactive oxygen metabolites (superoxide anion O2-) and lysosomal enzymes (lysozyme, N-acetyl-B-D-glucosaminidase) at specific time points (0, 6, 12, 24, 48, and 72 h) after initiation of acute lung injury via reverse passive Arthus reaction in pathogen-free Sprague-Dawley rats. After acute lung injury, stimulated PAM produced increasing amounts of O2- compared with PAM from noninjured lungs. Maximal O2- production by PAM occurred at 24 h after lung injury, at which time a 3.5-fold and 50% increase in O2- production by PAM was observed when PAM were stimulated with PMA and zymosan, respectively. The amount of O2- generated by these cells slowly decreased during the next 48 h. Enhanced generation of O2- by PAM from injured lungs was not due to altered enzymatic activity of the O2--producing NADPH oxidase, nor was it due to an absolute increase in the NADPH oxidase in "activated" PAM. These observations suggest that increased O2- generation by PAM from injured lungs is due to enhancement of mechanisms responsible for induction of oxidase activity. In addition, a differential accumulation and secretion of lysozyme and N-acetyl-B-D-glucosaminidase activity by PAM was observed after acute lung injury.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Pulmonary alveolar macrophage function during acute inflammatory lung injury. 303 76

The effect of the anti-IL-4 monoclonal antibody 11B11 mAb on antigen-induced footpad responses in mice in which Arthus reaction is involved was investigated. Antigen-induced footpad responses were induced by immunization with hen egg lysozyme (HEL) and by challenge injection of HEL into the footpads on day 20 after the immunization. Five hours after the challenge injection, footpad swelling was measured. 11B11 mAb was daily administered i.p. over a period of 10 days, commencing on the day of immunization with HEL. The results showed that the treatment with 11B11 mAb significantly augmented the footpad swelling. There was an increase in the production of anti-HEL IgG2a antibodies in 11B11 mAb-treated mice, while a decrease in anti-HEL IgG1 and IgG antibody production was observed in the animals. The secretion of IL-4 from lymphoid cells of 11B11 mAb-treated mice was markedly reduced. In contrast, increased IFN-gamma production was observed in these animals. Thus, treatment with anti-IL-4 antibodies appears to be effective in augmenting antibody-mediated in vivo responses in which antigen-specific IgG2a antibodies and IFN-gamma produced following the antibody treatment play a role.
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PMID:Augmented antibody-mediated footpad responses in mice treated with an anti-IL-4 monoclonal antibody. 940 43