Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.17 (lysozyme)
 21,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The behaviour of serum and urinary lysozyme was investigated before and after renal transplantation in 20 patients. The mean postoperative observation time was 67.8 (10 to 212) days. In 11 patients with reversible olig-anuria due to prolonged preoperative ischaemia, lysozymuria lasted for a period of 17 days after surgery, whereas in 8 patients with immediate transplant function lysozymuria disappeared 7 days after transplantation. Serum lysozyme concentrations were markedly elevated before transplantation in all patients. In patients with transplant failure due to ischaemia, normalization of serum lysozyme levels was achieved 28 days after surgery; patients with immediate function showed normal serum lysozyme levels already 7 days after transplantation. Prolonged lysozymuria was also noticed in 2 cases with irreversible ischaemic transplant failure, in 1 case with recurrence of glomerulonephritis and in 1 further case with acute pyelonephritis in the transplant. In 7 cases with an acute renal rejection crisis, lysozymuria was evident 0.7 days before clinical diagnosis of rejection. Serum lysozyme levels showed a strong correlation with serum correlation with serum creatinine concentrations. Therefore, lysozymuria in renal transplant patients indicates tubular transplant damage of varied aetiology. Elevated serum lysozyme levels, on the other hand, seem to reflect a reduced glomerular filtration rate.
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PMID:[Behaviour of serum and urinary lysozyme after renal transplantation (author's transl)]. 32 38

With the help of the haemofiltration on the capillary dialysator CDAK 4 the behaviour of lysozyme (muramidase) was investigated in 20 dialysis patients. In 6 of 55 cases a measurable lysozyme concentration in the haemofiltrate was found. A relation to the size of the serum lysozyme level could not be established. The influence of defective capillaries is discussed. Despite the in most cases not measurable lysozyme concentrations in the haemofiltrate a decrease of the serum lysozyme level taking place parallel to creatinine could be proved during dialysis. Examinations of the influence of the renal rest function in dialysis patients with a rest diuresis resulted in a lower lysozyme concentration in the serum than in patients with complete anuria. These findings allow conclusions to the behaviour of low-molecular proteins in the kidney of dialysis patients and to their losses on the dialysis membrane.
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PMID:[Hemofiltration of lysozyme in dialysis patients]. 52 74

The combination of renal tubular dysgenesis (RTD) and meconium ileus in a native Israeli is presented for the first time. The clinical diagnosis was oligohydramnios and abruptio placentae, respiratory failure, and anuria refractory to treatment. The autopsy revealed meconium ileus and meconium peritonitis. RTD was established by the detection of a monomorphous undifferentiated population of tubules, absence of proximal tubules, and dense epithelial membrane antigen immunoreactivity of all tubules. The lack of alpha 1-antitrypsin- and lysozyme-immunoreactive tubules was first revealed in the kidney with RTD. These findings extend the possibilities of RTD detection.
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PMID:Renal tubular dysgenesis present in a newborn with meconium ileus. 800 88

Renal tubular dysgenesis (RTD) is a very rare malformation. 48 cases have been described, mostly in North America, Europe and Israel. Histopathological examination plays a key role in its diagnosis of RTD. We present the results of a retrospective study documenting the frequency, clinical manifestations and pathological findings in RTD in the Upper and Eastern Galilee. In 343 perinatal autopsies performed in Safed and Nahariya Hospitals between 1974 and 1997, there were 5 cases with RTD. All were men, 3 were Druze and 2 were Jews. The parents of the Druze patients were first cousins; 2 cases were twins of whom 1 had RTD; intrauterine growth retardation was documented in 2 and oligohydramnios in 3 cases. Life span of 4 newborns ranged from 1.1 to 49 hours and was complicated by severe respiratory failure and anuria. Ultrasound and postmortem examinations revealed no pathology of the kidney and urinary tracts. Absence of the proximal tubules was supported by immunohistochemistry for epithelial membrane antigen. Our previous assumption about the importance of lysozyme immunostaining for diagnosis of RTD was confirmed by this larger series of cases and by statistical analysis. Because RTD is considered an autosomal recessive phenotype with a recurrence rate of 25%, there should be genetic counseling of the family in every case of RTD.
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PMID:[Renal tubular dysgenesis in upper and western Galilee]. 1090 56