Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.2.1.143 (poly(ADP-ribose) glycohydrolase)
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Human Gene/Protein
poly(ADP-ribose) glycohydrolase 17.2
PARG 16.2
ARH3 15.3
ARH2 15.2
PARG protein 15.2
ARH1 14.0
Poly(ADP-ribose) glycohydrolase 13.8
ARHGAP29 13.7
poly (ADP-ribose) glycohydrolase 13.4
NUDT7 13.3
FTCD 12.9
PARP3 12.9
PARP-2 12.7
ZBTB24 12.4
Poly(ADP-ribose) polymerase 12.0
ADP-ribose pyrophosphatase 11.9
P78 11.6
PARP-1 11.6
poly(ADP-ribose) polymerase 11.6
PAR 11.4
AML2 11.4
TNKS1 11.3
HPD 11.0
PARP1 10.9
poly(ADP-ribose) synthetase 10.7
G3BP 10.7
ADPRT 10.7
LIG 10.6
polynucleotide ligase 10.6
Poly(ADP-ribose)polymerase 10.6
mitofilin 10.6
Cap43 10.5
P49 10.5
P33 10.5
FAS ligand 10.4
melastatin 2 10.3
NDR1 10.2
E25 10.2
apoptosis-inducing factor 10.0
ADP-ribosyl cyclase 10.0
more...
Disease
tubulovillous adenoma 9.9
villous adenoma 8.3
PME 8.1
ATRX 7.9
Borna disease 7.8
erythroblastosis 7.7
Worms 7.7
chemical carcinogenesis 6.8
endotoxic shock 6.8
mammary tumor 5.5
fragile X syndrome 5.4
familial adenomatous polyposis 5.1
lung metastases 4.8
cerebral ischemia 4.8
ATM 4.6
carcinogenesis 4.4
worms 4.2
Chagas 4.2
Blocking 4.1
glioblastoma 4.1
hyperthyroidism 3.9
diabetic nephropathy 3.8
ischemia 3.7
epithelial ovarian cancer 3.7
herpes simplex 3.4
parkinsonism 3.4
mental retardation 3.3
mental retardation 3.3
osteosarcoma 3.2
acute myeloid leukemia 3.1
colitis 3.0
lupus 2.8
autoimmune disease 2.6
ovarian cancer 2.4
MCF 2.4
tumorigenesis 2.4
malnutrition 2.4
chronic obstructive pulmonary disease 2.4
prostate cancer 2.4
glioma 2.3
more...
Symptom
seizures 0.9
Drug
Tannic acid 8.6
Pronase 6.9
DNase I 4.2
ROS 3.0
lysine 1.4
Dermatol -0.8
Enzyme
poly(ADP-ribose) glycohydrolase 17.2
NAD glycohydrolase 10.5
venom phosphodiesterase 10.4
nicotinamide mononucleotide adenylyltransferase 10.2
PARP 10.2
3'-phosphatase 9.8
nicotinamide phosphoribosyltransferase 9.7
folylpolyglutamate synthetase 8.8
PME 8.7
cellulose synthase 7.9
polynucleotide kinase 7.8
pectin methylesterase 7.7
C3 convertase 7.4
cellulose synthase 6.9
phosphodiesterase 6.0
DNA ligase 5.8
DNA ligase 5.8
micrococcal nuclease 5.8
DNase 5.3
CPR 4.9
diaphorase 4.7
NOS 4.4
thymidine kinase 4.3
DNA polymerase 4.2
endonuclease 4.0
NADPH oxidase 3.9
NADPH oxidase 3.8
caspase-3 3.7
P-glycoprotein 3.5
lactate dehydrogenase 3.4
NO synthase 3.3
RNase 3.2
RNase 3.1
glutathione S-transferase 2.8
alkaline phosphatase 2.7
catalase 2.5
superoxide dismutase 2.4
luciferase 2.0
ACS 2.0
focal adhesion kinase 1.8
more...
Compound
9H-fluoren-9-one 12.8
9H-fluoren-9-one 12.8
9H-fluoren-9-one 12.7
9H-fluoren-9-one 12.0
ADP-ribose 11.5
Proflavine 11.5
PAR 11.4
Tilorone 11.1
Nedaplatin 11.1
3-methoxybenzamide 10.9
TCTP 10.5
Tannin 10.4
3'-AMP 9.7
3-aminobenzamide 8.9
Ethidium bromide 8.7
MNNG 8.7
ADP 8.5
ADP 8.5
ADP 8.4
m-AMSA 8.2
NAD 8.1
NAD 8.0
benzamide 7.6
DEA 7.6
DEA 7.6
DEA 7.5
tetraphosphate 7.4
nicotinamide 7.1
2-nonenal 6.5
PPi 6.2
adenylate 6.2
GAP 6.2
Cyt 5.7
Androgen 5.6
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 5.6
Adenosine 5.5
asparagine 5.3
PEI 5.2
PEI 5.2
Histone 5.0
more...