Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.2.1.108 (lactase)
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Human Gene/Protein
KBTBD3 13.9
carcinoembryonic antigen-related protein 13.9
taste receptor, type 2, member 38 13.9
ANKRD35 13.9
lactase 13.8
lactase-phlorizin hydrolase 13.7
Maltase 12.2
HLAL 11.9
sucrase-isomaltase 11.7
maltase-glucoamylase 11.6
lysosomal acid beta-galactosidase 11.4
Mis5 11.1
Maltase-glucoamylase 11.1
TUBGCP4 11.1
trehalase 11.0
TREH 10.9
alpha-kinase 1 10.9
AADAC 10.7
TFIP11 10.5
LCT 10.3
MCM6 10.3
LPH 10.1
sodium-dependent glucose transporter 1 9.9
BOAT 9.9
ARHGAP11B 9.9
Trehalase 9.8
zinc finger protein 36 9.6
elastin binding protein 9.5
brush border 9.3
aminopeptidase N 9.3
HOXC11 9.2
Glucoamylase 9.2
GLP-2R 9.1
Maid 9.1
cytosolic beta-glucosidase 8.9
intestinal alkaline phosphatase 8.9
alkaline sphingomyelinase 8.8
epsin 1 8.7
leucine aminopeptidase 8.7
cellular retinol binding protein II 8.7
SGLT1 8.6
enterokinase 8.6
cytokeratin 4 8.5
SLC30A1 8.5
Foxl1 8.5
MT-ND5 8.5
TOLLIP 8.5
Enh 8.4
sodium/glucose cotransporter 8.4
KLG 8.4
GLP-2 receptor 8.3
Na+/glucose cotransporter 8.3
SLC39A4 8.3
GLUT5 8.3
Beta-galactosidase 8.3
POU2F1 8.2
BCO2 8.0
sodium-dependent glucose transporter 8.0
aminopeptidase 8.0
large allele 7.9
DPP10 7.9
ALDH1L1 7.9
alpha-glucosidase 7.9
peptide transporter 1 7.9
ASIP 7.9
HNF1alpha 7.8
LI-cadherin 7.8
dipeptidyl peptidase IV 7.8
PCK2 7.8
GATA-6 7.8
congenital chloride diarrhea 7.7
AMY 7.7
DNA replication licensing factor 7.7
phosphoserine aminotransferase 7.7
lysosomal alpha-glucosidase 7.6
Rhes 7.6
claudin 2 7.6
neutral ceramidase 7.5
SLC24A5 7.5
Lysophospholipase 7.5
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Disease
Congenital lactase deficiency 13.9
Trehalase deficiency 13.9
Primary hypolactasia 13.9
Lactose intolerant 12.9
Secondary lactose intolerance 12.6
disaccharidase deficiency 12.6
lactose intolerance 12.1
mild intolerance 11.9
Food sensitivity 11.9
CSID 10.1
Aquagenic urticaria 10.0
Milk allergy 9.8
metagonimiasis 8.6
malabsorption 8.6
Meconium ileus 8.6
intestinal neoplasm 8.4
vitamin B deficiency 8.3
viral enteritis 8.2
stage I ovarian cancer 8.2
Crohn's ileitis 8.2
chylomicron retention disease 8.2
Tokelau 7.9
blind loop syndrome 7.8
Immunoproliferative small intestinal disease 7.8
Jejunum 7.7
Infection induced 7.7
Laurence-Moon-Biedl syndrome 7.6
sprue 7.5
tropical sprue 7.5
glucose-galactose malabsorption 7.5
Intestinal infection 7.4
giardiasis 7.4
cryptitis 7.3
HND 7.2
pancreatic insufficiency 7.2
acrodermatitis enteropathica 7.0
Oral infection 6.9
enzyme deficiency 6.9
gastric retention 6.9
IRD 6.9
favism 6.8
Acute gastroenteritis 6.8
steatorrhea 6.8
Cronkhite-Canada syndrome 6.7
gastroduodenitis 6.7
laxative abuse 6.6
Schmitz 6.6
kwashiorkor 6.5
Alveolar soft part sarcoma 6.4
HBT 6.4
infectious gastroenteritis 6.3
Growth failure 6.2
Plasmodium vivax infection 6.2
hypobetalipoproteinemia 6.2
menstrual migraine 6.2
kidney hypertrophy 6.2
Small intestine 6.2
bacterial diarrhea 6.1
acute diarrhea 6.0
Functional dyspepsia 6.0
hypochloremia 5.9
gastrointestinal disease 5.9
irritable bowel syndrome 5.9
celiac disease 5.9
enteropathy 5.8
acanthocytosis 5.8
dental calculus 5.8
short bowel syndrome 5.7
SBS 5.5
SBS 5.5
failure to thrive 5.4
Whipple's disease 5.4
splenic marginal zone lymphoma 5.3
agammaglobulinemia 5.2
nutritional disorder 5.2
necrotizing enterocolitis 5.2
duodenitis 5.2
schizotypal personality disorder 5.2
gluten sensitivity 5.2
galactosemia 5.2
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Symptom
Food intolerance 9.7
Mucosal hyperplasia 9.6
Infantile colic 8.0
bloating 7.9
Wind 7.2
autodigestion 7.1
infant diarrhea 7.1
belching 6.8
asterixis 6.2
stomach pain 5.9
diarrhea 5.7
Gastrointestinal symptoms 5.7
abdominal discomfort 5.4
colic 5.2
abdominal cramps 4.8
chronic constipation 4.5
abdominal pain 4.2
general problem 4.1
DNA marker 4.0
orofacial pain 4.0
emaciation 3.8
microbial colonization 3.8
eds 3.8
starvation 3.4
bitter taste 3.4
exertional dyspnea 3.1
heartburn 2.8
constipation 2.5
asthenia 2.5
discomfort 2.4
discomfort 2.3
myalgia 2.2
cerebellar ataxia 2.0
acute pain 1.9
regurgitation 1.9
vomiting 1.7
anorexia 1.7
nausea 1.7
ENT 1.5
cachexia 1.4
hunger 1.4
hemoptysis 1.3
acidity 1.0
tremor 0.7
syncope 0.7
distraction 0.7
dizziness 0.6
splenomegaly 0.6
thinning 0.4
functional recovery 0.2
exhaustion 0.1
headache 0.1
Welt -0.1
fatigue -0.2
hypothermia -0.2
pain -0.3
weakness -0.3
respiratory distress -0.4
cough -0.7
overweight -0.8
anesthesia -1.3
seizures -2.4
Drug
Lactase 13.4
Lactose 10.1
Gluconolactone 9.6
Tuareg 9.2
lactose 9.2
Miglustat 8.2
Sodium carbonate 8.1
Galactose 7.3
Fluticasone propionate 7.0
beta-Galactosidase 6.7
Carbidopa 6.5
APM 6.4
CDX 5.9
Nimesulide 5.6
Fructose 5.6
CDX 5.4
Tannic acid 5.3
Bifidobacterium 5.2
Maltose 5.0
Monensin 5.0
Sinemet 4.8
Emodin 4.7
Vitamin B 4.6
Secretin 4.3
Cimetidine 4.2
Irinotecan 4.2
Cimetidine 4.2
MgSO4 3.3
GEO 3.3
NaI 3.0
NaI 3.0
NaI 3.0
NaI 3.0
Glucagon 3.0
CPT-11 3.0
Ethanol 2.9
Propofol 2.8
Fragment 2.7
CDP 2.7
L-tyrosine 2.7
citric acid 2.6
Fraction 2.5
Forskolin 2.5
DNase I 2.4
ALA 2.4
Growth hormone 2.3
Nephron 2.3
Growth hormone 2.3
Leaf 2.3
CaCl2 2.2
CaCl2 2.2
CaCl2 2.2
MRC 2.1
HCH 2.1
Gel 2.0
Fluorescein 2.0
Portal 1.8
Nephron 1.7
Albumin 1.6
ZnO 1.1
lysine 1.0
THF 0.9
ENT 0.8
Asn 0.3
IL-2 0.0
MAP -0.1
Monit -0.2
ROS -0.4
caffeine -0.5
IFN-gamma -1.0
Dermatol -3.1
Enzyme
lactase 13.9
lactase-phlorizin hydrolase 13.8
lactase-phlorizin hydrolase 13.7
sucrase 12.1
dipeptidyl-dipeptidase 11.9
sucrase-isomaltase 11.6
invertase 11.0
alpha-glucosidase 11.0
trehalase 10.9
D-galactose dehydrogenase 9.5
aminopeptidase A 9.2
glucoamylase 9.2
leucine aminopeptidase 8.6
monoacylglycerol acyltransferase 8.2
enterokinase 8.2
DAP II 8.1
allantoicase 8.0
beta-glucosidase 8.0
dipeptidyl peptidase IV 8.0
CD13 8.0
levanase 7.9
beta-D-fucosidase 7.9
tripeptidase 7.8
prolinase 7.7
inulinase 7.7
levanase 7.7
conjugase 7.3
ketohexokinase 7.2
beta-galactosidase 7.2
uridine kinase 7.2
inulinase 7.1
EC 2.7.7.9 6.9
penicillopepsin 6.9
beta-glucosidase 6.9
phosphoserine aminotransferase 6.9
dextranase 6.8
dihydroorotase 6.7
phosphoketolase 6.7
lichenase 6.6
chymosin 6.6
alkaline phosphatase 6.4
triose-phosphate isomerase 6.3
gamma-glutamyl transpeptidase 6.2
EC 1.1.1.40 6.2
galactocerebrosidase 6.2
aspartase 6.1
uridyltransferase 6.1
feruloyl esterase 6.1
alpha-amylase 6.1
diamine oxidase 5.9
alpha-L-fucosidase 5.9
alpha-L-fucosidase 5.8
proteinase A 5.8
5'-nucleotidase 5.7
penicillin acylase 5.6
galactokinase 5.6
carbamoylphosphate synthetase 5.6
PNL 5.5
glucose-6-phosphatase 5.4
fructokinase 5.4
alpha-L-fucosidase 5.3
cathepsin C 5.3
galactose oxidase 5.2
alpha-galactosidase 5.1
aspartate transcarbamylase 5.1
PTR 5.1
beta-amylase 5.1
endoglycosidase H 5.0
polyamine oxidase 5.0
glucosylceramide synthase 5.0
hexosaminidase 4.9
cellulase 4.9
MDP 4.8
estrogen sulfotransferase 4.7
carboxypeptidase B 4.6
p-nitrophenylphosphatase 4.6
CPS 4.6
furin 4.5
papain 4.5
beta-1,3-glucanase 4.5
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Compound
Pachyman 11.9
Lactose 10.0
Ammonium dihydrogen phosphate 10.0
L-Phenylalanine, 9.9
heptitol 9.1
heptitol 9.1
heptitol 9.1
L-Phenylalanine, 9.0
Cortisone acetate 9.0
heptitol 8.9
Gluconolactone 8.9
L-Arabinose 8.9
Palatinose 8.8
Castanospermine 8.6
Laminariaceae 8.5
2-methylbutanal 8.3
Maltotriose 8.2
Embelin 8.0
DMDP 7.9
Acacetin 7.9
Calycosin 7.6
BBM 7.6
Cortisone 7.6
Azoxymethane 7.5
PGB2 7.4
Triolein 7.3
Galactose 7.3
Lactulose 6.9
beta-D-galactoside 6.5
1,5-AG 6.5
SHA 6.4
Acarbose 6.3
fructose-1-phosphate 6.3
Benzyl alcohol 6.3
Pyridoxine 6.3
Bantu 6.3
Pentagastrin 6.2
NDS 6.1
2-naphthyl 6.1
Trehalose 6.1
Thyroxine 6.1
Acetyl-L-carnitine 6.1
Carbofuran 6.0
D-galactopyranosyl 6.0
SPM 5.9
MGBG 5.9
MGBG 5.9
Gossypol 5.9
Gossypol 5.9
Deoxycholic acid 5.8
Leupeptin 5.7
PCMB 5.7
PCMB 5.7
PCMB 5.7
NMN 5.7
Taurocholate 5.7
PGA2 5.7
PCMB 5.6
Neomycin 5.6
Span 80 5.5
Fructose 5.5
Streptomycin 5.4
Leupeptin 5.4
HEI 5.3
galactose 5.3
GAL 5.2
Ural 5.2
L-leucine 5.2
PTR 5.2
Kanamycin 5.1
xylose 5.1
Lawson 5.1
HCP 5.1
ethyl acrylate 5.0
Monensin 5.0
APN 5.0
Maltose 5.0
Pectin 5.0
Xylose 5.0
ETH 5.0
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