Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.2.1.108 (lactase)
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Human Gene/Protein
KBTBD3 13.9
taste receptor, type 2, member 38 13.9
carcinoembryonic antigen-related protein 13.9
ANKRD35 13.9
lactase 13.8
lactase-phlorizin hydrolase 13.7
Maltase 12.2
HLAL 11.9
sucrase-isomaltase 11.7
maltase-glucoamylase 11.6
lysosomal acid beta-galactosidase 11.4
TUBGCP4 11.1
Mis5 11.1
Maltase-glucoamylase 11.1
trehalase 11.0
TREH 10.9
alpha-kinase 1 10.9
AADAC 10.7
TFIP11 10.5
LCT 10.3
MCM6 10.3
LPH 10.1
BOAT 9.9
sodium-dependent glucose transporter 1 9.9
ARHGAP11B 9.9
Trehalase 9.8
zinc finger protein 36 9.6
elastin binding protein 9.5
brush border 9.3
aminopeptidase N 9.3
HOXC11 9.2
Glucoamylase 9.2
GLP-2R 9.1
Maid 9.1
cytosolic beta-glucosidase 8.9
intestinal alkaline phosphatase 8.9
alkaline sphingomyelinase 8.8
epsin 1 8.7
leucine aminopeptidase 8.7
cellular retinol binding protein II 8.7
SGLT1 8.6
enterokinase 8.6
SLC30A1 8.5
cytokeratin 4 8.5
Foxl1 8.5
MT-ND5 8.5
TOLLIP 8.5
Enh 8.4
sodium/glucose cotransporter 8.4
KLG 8.4
GLP-2 receptor 8.3
Na+/glucose cotransporter 8.3
SLC39A4 8.3
GLUT5 8.3
Beta-galactosidase 8.3
POU2F1 8.2
BCO2 8.0
sodium-dependent glucose transporter 8.0
aminopeptidase 8.0
DPP10 7.9
large allele 7.9
ALDH1L1 7.9
alpha-glucosidase 7.9
peptide transporter 1 7.9
ASIP 7.9
HNF1alpha 7.8
LI-cadherin 7.8
dipeptidyl peptidase IV 7.8
PCK2 7.8
GATA-6 7.8
congenital chloride diarrhea 7.7
AMY 7.7
phosphoserine aminotransferase 7.7
DNA replication licensing factor 7.7
Rhes 7.6
lysosomal alpha-glucosidase 7.6
claudin 2 7.6
neutral ceramidase 7.5
SLC24A5 7.5
Lysophospholipase 7.5
CD26 7.5
uridine kinase 7.5
SLC7A1 7.4
CCAT 7.4
Phosphoglucomutase 7.4
motilin receptor 7.4
L-FABP 7.4
LNP 7.3
PEPT1 7.2
urogastrone 7.2
plakophilin 7.2
GLUT-2 7.1
Alkaline phosphatase 7.1
AMY1 7.1
EDD 7.0
FABP2 7.0
claudin 4 7.0
cysteine string protein 7.0
DPP IV 6.9
GATA-4 6.9
mucin 2 6.9
diamine oxidase 6.9
I-FABP 6.9
GLUT2 6.8
B(0)AT1 6.8
Apolipoprotein A-IV 6.8
LSH 6.8
enteropeptidase 6.8
HERC2 6.7
EDAR 6.7
HBD-2 6.7
Aminopeptidase 6.7
N-acetyl-beta-glucosaminidase 6.7
gamma-glutamyl transpeptidase 6.7
HST 6.7
Diamine oxidase 6.6
GPR43 6.6
claudin 3 6.6
SAB 6.6
tropomodulin 6.6
ZO-2 6.5
gamma-glutamyltransferase 6.5
gamma-glutamyltranspeptidase 6.5
Nuclear protein 6.5
carbohydrate response element binding protein 6.4
TYRP1 6.4
villin 6.4
alkaline phosphatase 6.4
fructose transporter 6.4
PNG 6.3
L100 6.3
ATP pyrophosphate-lyase 6.2
Oct-1 6.2
PACE4 6.2
gastric lipase 6.2
Cap43 6.2
gastrointestinal peptide 6.2
acid alpha-glucosidase 6.1
Glucose-6-phosphatase 6.1
TYR 6.1
T1R2 6.1
claudin-2 6.1
COL4A3 6.1
ADH1B 6.1
RFI 6.1
alpha-amylase 6.1
GLD 6.0
insulin-like growth factor binding protein-4 6.0
fructokinase 6.0
INSR 6.0
TFF3 6.0
GH2 5.9
A-3 5.9
beta polypeptide 5.9
DAO 5.9
Claudin-1 5.8
DARC 5.8
calbindin-D9k 5.8
apolipoprotein A-IV 5.8
aquaporin 1 5.8
more...
Disease
Congenital lactase deficiency 13.9
Primary hypolactasia 13.9
Trehalase deficiency 13.9
Lactose intolerant 12.9
Secondary lactose intolerance 12.6
disaccharidase deficiency 12.6
lactose intolerance 12.1
mild intolerance 11.9
Food sensitivity 11.9
CSID 10.1
Aquagenic urticaria 10.0
Milk allergy 9.8
metagonimiasis 8.6
malabsorption 8.6
Meconium ileus 8.6
intestinal neoplasm 8.4
vitamin B deficiency 8.3
viral enteritis 8.2
stage I ovarian cancer 8.2
Crohn's ileitis 8.2
chylomicron retention disease 8.2
Tokelau 7.9
blind loop syndrome 7.8
Immunoproliferative small intestinal disease 7.8
Jejunum 7.7
Infection induced 7.7
Laurence-Moon-Biedl syndrome 7.6
sprue 7.5
tropical sprue 7.5
glucose-galactose malabsorption 7.5
Intestinal infection 7.4
giardiasis 7.4
cryptitis 7.3
HND 7.2
pancreatic insufficiency 7.2
acrodermatitis enteropathica 7.0
Oral infection 6.9
enzyme deficiency 6.9
gastric retention 6.9
IRD 6.9
favism 6.8
Acute gastroenteritis 6.8
steatorrhea 6.8
Cronkhite-Canada syndrome 6.7
gastroduodenitis 6.7
laxative abuse 6.6
Schmitz 6.6
kwashiorkor 6.5
Alveolar soft part sarcoma 6.4
HBT 6.4
infectious gastroenteritis 6.3
Growth failure 6.2
Plasmodium vivax infection 6.2
hypobetalipoproteinemia 6.2
menstrual migraine 6.2
Small intestine 6.2
kidney hypertrophy 6.2
bacterial diarrhea 6.1
acute diarrhea 6.0
Functional dyspepsia 6.0
gastrointestinal disease 5.9
hypochloremia 5.9
irritable bowel syndrome 5.9
celiac disease 5.9
enteropathy 5.8
acanthocytosis 5.8
dental calculus 5.8
short bowel syndrome 5.7
SBS 5.5
SBS 5.5
failure to thrive 5.4
Whipple's disease 5.4
splenic marginal zone lymphoma 5.3
agammaglobulinemia 5.2
nutritional disorder 5.2
necrotizing enterocolitis 5.2
schizotypal personality disorder 5.2
duodenitis 5.2
gluten sensitivity 5.2
galactosemia 5.2
anal atresia 5.2
PRRS 5.2
aminoaciduria 5.2
pellagra 5.2
trisomy 13 5.1
enteritis 5.1
enterocolitis 5.1
marasmus 5.1
Atrophic 5.0
hypervitaminosis 4.9
gastroschisis 4.9
protein deficiency 4.8
dermatitis herpetiformis 4.8
viral diarrhea 4.8
immaturity 4.8
dyspepsia 4.8
organic disease 4.8
PTR 4.7
Autoimmune hepatitis 4.7
food allergy 4.7
chromoblastomycosis 4.7
Gaucher disease 4.6
malnutrition 4.6
intestinal cancer 4.6
GSD 4.6
gastrointestinal infection 4.5
Ovarian Cancer 4.5
Niemann-Pick 4.5
postmenopausal bone loss 4.5
adenocarcinoma of the stomach 4.4
duodenal ulcer 4.4
GSD 4.4
RTS 4.3
DLBCL 4.3
cryptosporidiosis 4.2
ascariasis 4.2
FMD 4.2
NPH 4.1
intestinal parasites 4.1
Luminal 4.0
rectal prolapse 4.0
gastroenteritis 4.0
ulcerative colitis 4.0
Crohn's disease 3.9
vitamin A deficiency 3.9
protein-losing enteropathy 3.9
morbid obesity 3.8
diverticular disease 3.8
LCP 3.8
PER 3.7
hereditary hemochromatosis 3.6
Krabbe disease 3.6
wasting syndrome 3.6
atrophic gastritis 3.6
Klinefelter's syndrome 3.5
trichinellosis 3.5
inflammatory bowel disease 3.5
Diffuse large B-cell lymphoma 3.5
cystic fibrosis 3.5
glycogen storage disease 3.5
Hymenolepis 3.5
gastroparesis 3.4
pernicious anemia 3.4
iron deficiency 3.4
nephrocalcinosis 3.4
hepatic encephalopathy 3.4
FMD 3.4
Fox 3.4
ileus 3.4
porphyria 3.3
osteoporosis 3.3
lymphangioleiomyomatosis 3.3
osteomalacia 3.2
AIN 3.2
AAS 3.2
hypernatremia 3.2
gastritis 3.2
folate deficiency 3.2
colibacillosis 3.2
ash 3.2
more...
Symptom
Food intolerance 9.7
Mucosal hyperplasia 9.6
Infantile colic 8.0
bloating 7.9
Wind 7.2
autodigestion 7.1
infant diarrhea 7.1
belching 6.8
asterixis 6.2
stomach pain 5.9
diarrhea 5.7
Gastrointestinal symptoms 5.7
abdominal discomfort 5.4
colic 5.2
abdominal cramps 4.8
chronic constipation 4.5
abdominal pain 4.2
general problem 4.1
DNA marker 4.0
orofacial pain 4.0
emaciation 3.8
microbial colonization 3.8
eds 3.8
starvation 3.4
bitter taste 3.4
exertional dyspnea 3.1
heartburn 2.8
constipation 2.5
asthenia 2.5
discomfort 2.4
discomfort 2.3
myalgia 2.2
cerebellar ataxia 2.0
acute pain 1.9
regurgitation 1.9
vomiting 1.7
anorexia 1.7
nausea 1.7
ENT 1.5
cachexia 1.4
hunger 1.4
hemoptysis 1.3
acidity 1.0
tremor 0.7
syncope 0.7
distraction 0.7
dizziness 0.6
splenomegaly 0.6
thinning 0.4
functional recovery 0.2
exhaustion 0.1
headache 0.1
Welt -0.1
fatigue -0.2
hypothermia -0.2
pain -0.3
weakness -0.3
respiratory distress -0.4
cough -0.7
overweight -0.8
anesthesia -1.3
seizures -2.4
Drug
Lactase 13.4
Lactose 10.1
Gluconolactone 9.6
Tuareg 9.2
lactose 9.2
Miglustat 8.2
Sodium carbonate 8.1
Galactose 7.3
Fluticasone propionate 7.0
beta-Galactosidase 6.7
Carbidopa 6.5
APM 6.4
CDX 5.9
Nimesulide 5.6
Fructose 5.6
CDX 5.4
Tannic acid 5.3
Bifidobacterium 5.2
Maltose 5.0
Monensin 5.0
Sinemet 4.8
Emodin 4.7
Vitamin B 4.6
Secretin 4.3
Cimetidine 4.2
Irinotecan 4.2
Cimetidine 4.2
MgSO4 3.3
GEO 3.3
NaI 3.0
NaI 3.0
NaI 3.0
NaI 3.0
Glucagon 3.0
CPT-11 3.0
Ethanol 2.9
Propofol 2.8
Fragment 2.7
CDP 2.7
L-tyrosine 2.7
citric acid 2.6
Fraction 2.5
Forskolin 2.5
DNase I 2.4
ALA 2.4
Growth hormone 2.3
Nephron 2.3
Growth hormone 2.3
Leaf 2.3
CaCl2 2.2
CaCl2 2.2
CaCl2 2.2
MRC 2.1
HCH 2.1
Gel 2.0
Fluorescein 2.0
Portal 1.8
Nephron 1.7
Albumin 1.6
ZnO 1.1
lysine 1.0
THF 0.9
ENT 0.8
Asn 0.3
IL-2 0.0
MAP -0.1
Monit -0.2
ROS -0.4
caffeine -0.5
IFN-gamma -1.0
Dermatol -3.1
Enzyme
lactase 13.9
lactase-phlorizin hydrolase 13.8
lactase-phlorizin hydrolase 13.7
sucrase 12.1
dipeptidyl-dipeptidase 11.9
sucrase-isomaltase 11.6
invertase 11.0
alpha-glucosidase 11.0
trehalase 10.9
D-galactose dehydrogenase 9.5
aminopeptidase A 9.2
glucoamylase 9.2
leucine aminopeptidase 8.6
monoacylglycerol acyltransferase 8.2
enterokinase 8.2
DAP II 8.1
allantoicase 8.0
beta-glucosidase 8.0
dipeptidyl peptidase IV 8.0
CD13 8.0
levanase 7.9
beta-D-fucosidase 7.9
tripeptidase 7.8
prolinase 7.7
inulinase 7.7
levanase 7.7
conjugase 7.3
ketohexokinase 7.2
beta-galactosidase 7.2
uridine kinase 7.2
inulinase 7.1
EC 2.7.7.9 6.9
penicillopepsin 6.9
beta-glucosidase 6.9
phosphoserine aminotransferase 6.9
dextranase 6.8
dihydroorotase 6.7
phosphoketolase 6.7
lichenase 6.6
chymosin 6.6
alkaline phosphatase 6.4
triose-phosphate isomerase 6.3
gamma-glutamyl transpeptidase 6.2
EC 1.1.1.40 6.2
galactocerebrosidase 6.2
aspartase 6.1
uridyltransferase 6.1
feruloyl esterase 6.1
alpha-amylase 6.1
diamine oxidase 5.9
alpha-L-fucosidase 5.9
alpha-L-fucosidase 5.8
proteinase A 5.8
5'-nucleotidase 5.7
penicillin acylase 5.6
galactokinase 5.6
carbamoylphosphate synthetase 5.6
PNL 5.5
glucose-6-phosphatase 5.4
fructokinase 5.4
alpha-L-fucosidase 5.3
cathepsin C 5.3
galactose oxidase 5.2
alpha-galactosidase 5.1
aspartate transcarbamylase 5.1
PTR 5.1
beta-amylase 5.1
endoglycosidase H 5.0
polyamine oxidase 5.0
glucosylceramide synthase 5.0
hexosaminidase 4.9
cellulase 4.9
MDP 4.8
estrogen sulfotransferase 4.7
carboxypeptidase B 4.6
p-nitrophenylphosphatase 4.6
CPS 4.6
furin 4.5
papain 4.5
beta-1,3-glucanase 4.5
beta-1,3-glucanase 4.4
argininosuccinate synthetase 4.4
lipase 4.4
pepsin 4.4
pullulanase 4.4
glucocerebrosidase 4.3
alanine aminopeptidase 4.3
alpha-mannosidase 4.3
acid phosphatase 4.3
glucose oxidase 4.3
CFI 4.2
acyl-CoA synthetase 4.2
beta-glucuronidase 4.1
succinic dehydrogenase 4.1
acylase 4.0
ornithine decarboxylase 4.0
Pla 4.0
trypsin 4.0
BIS 4.0
glucokinase 4.0
carboxypeptidase A 3.9
chymotrypsin 3.9
nucleotidase 3.9
neuropathy target esterase 3.8
proprotein convertase 3.8
pectinase 3.6
thymidine kinase 3.6
acyl-CoA synthetase 3.5
transketolase 3.5
hexokinase 3.5
phosphoglucomutase 3.5
succinate dehydrogenase 3.5
xylanase 3.4
transpeptidase 3.4
subtilisin 3.4
aldehyde dehydrogenase 3.4
aldehyde dehydrogenase 3.4
xylanase 3.3
aldehyde dehydrogenase 3.3
Mg2+-ATPase 3.3
pyruvate carboxylase 3.3
elastase 3.3
PNGase F 3.3
glyceraldehyde-3-phosphate dehydrogenase 3.3
transglutaminase 3.2
ornithine transcarbamylase 3.1
aldehyde dehydrogenase 3.1
pyruvate kinase 3.1
urease 3.0
enolase 3.0
urease 3.0
glyceraldehyde-3-phosphate dehydrogenase 3.0
RNase 2.9
phosphoenolpyruvate carboxykinase 2.8
phosphoenolpyruvate carboxykinase 2.8
methylenetetrahydrofolate reductase 2.8
methylenetetrahydrofolate reductase 2.8
NADH dehydrogenase 2.8
glyceraldehyde-3-phosphate dehydrogenase 2.8
aldehyde dehydrogenase 2.8
glyceraldehyde-3-phosphate dehydrogenase 2.8
glyceraldehyde-3-phosphate dehydrogenase 2.8
ribonuclease 2.8
ribonuclease 2.8
phosphoenolpyruvate carboxykinase 2.7
neuraminidase 2.6
ATPase 2.6
lactate dehydrogenase 2.6
RNase 2.5
adenosine deaminase 2.5
glucose-6-phosphate dehydrogenase 2.5
adenosine deaminase 2.5
SPC 2.5
monoamine oxidase 2.5
myosin light chain kinase 2.5
phosphorylase 2.4
lysozyme 2.3
isocitrate dehydrogenase 2.3
caspase-1 2.2
sulfatase 2.2
more...
Compound
Pachyman 11.9
Lactose 10.0
Ammonium dihydrogen phosphate 10.0
L-Phenylalanine, 9.9
heptitol 9.1
heptitol 9.1
heptitol 9.1
L-Phenylalanine, 9.0
Cortisone acetate 9.0
heptitol 8.9
Gluconolactone 8.9
L-Arabinose 8.9
Palatinose 8.8
Castanospermine 8.6
Laminariaceae 8.5
2-methylbutanal 8.3
Maltotriose 8.2
Embelin 8.0
DMDP 7.9
Acacetin 7.9
Calycosin 7.6
BBM 7.6
Cortisone 7.6
Azoxymethane 7.5
PGB2 7.4
Triolein 7.3
Galactose 7.3
Lactulose 6.9
1,5-AG 6.5
beta-D-galactoside 6.5
SHA 6.4
Acarbose 6.3
fructose-1-phosphate 6.3
Benzyl alcohol 6.3
Pyridoxine 6.3
Bantu 6.3
Pentagastrin 6.2
NDS 6.1
2-naphthyl 6.1
Trehalose 6.1
Thyroxine 6.1
Acetyl-L-carnitine 6.1
Carbofuran 6.0
D-galactopyranosyl 6.0
SPM 5.9
MGBG 5.9
MGBG 5.9
Gossypol 5.9
Gossypol 5.9
Deoxycholic acid 5.8
Leupeptin 5.7
PCMB 5.7
PCMB 5.7
PCMB 5.7
Taurocholate 5.7
NMN 5.7
PGA2 5.7
PCMB 5.6
Neomycin 5.6
Span 80 5.5
Fructose 5.5
Streptomycin 5.4
Leupeptin 5.4
HEI 5.3
galactose 5.3
GAL 5.2
Ural 5.2
L-leucine 5.2
PTR 5.2
Kanamycin 5.1
xylose 5.1
Lawson 5.1
HCP 5.1
ethyl acrylate 5.0
Monensin 5.0
APN 5.0
Maltose 5.0
Pectin 5.0
ETH 5.0
Xylose 5.0
Glutamine 4.9
Sphingomyelin 4.9
Acyl-CoA 4.9
HCP 4.8
B17 4.8
Sucrose 4.8
Triiodothyronine 4.7
Cortisol 4.7
Sialic acid 4.7
carbamyl phosphate 4.7
Carrageenan 4.7
Zearalenone 4.6
Deoxynivalenol 4.6
Leucine 4.6
hexose 4.6
hexose 4.6
hexose 4.6
Deoxyribonucleic acid 4.6
Tempol 4.6
Mannitol 4.5
Gb3 4.5
Phorbol 12-myristate 13-acetate 4.5
Mannitol 4.4
ETH 4.4
SO3 4.4
Secretin 4.3
butyric acid 4.3
Actinomycin D 4.2
butyric acid 4.2
Polypeptide 4.1
butyric acid 4.1
carbonic acid 4.1
hexose 4.1
Glutaraldehyde 4.0
Celecoxib 4.0
Neurotensin 4.0
Putrescine 3.9
DPI 3.9
Corticosterone 3.9
Tween 20 3.9
AGE 3.9
glucose 3.9
alloxan 3.9
FAP 3.9
FAP 3.9
Eosin 3.9
carbonic acid 3.8
Quercetin 3.8
2-naphthol 3.8
2-naphthol 3.8
2-naphthol 3.8
CdCl2 3.8
Trypsin 3.8
stearic acid 3.7
stearic acid 3.7
DAP 3.7
L-T3 3.7
DAP 3.7
UMP 3.7
COS 3.7
stearic acid 3.7
Triton X-100 3.7
Eosin 3.6
Dexamethasone 3.6
Tris 3.5
Glyphosate 3.5
1,3,5-hexatriene 3.5
1,3,5-hexatriene 3.5
Neu5Ac 3.5
1,3,5-hexatriene 3.5
1,2-dimethylhydrazine 3.5
hydrogen 3.4
leucine 3.4
Agarose 3.3
Tris 3.3
Amide 3.3
BHT 3.3
vitamin D 3.3
DIDS 3.2
CDP 3.2
more...