Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.108 (
lactase
)
2,133
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We have determined the sequence of a 2784 bp rat genomic fragment originating from the 5' region of the gene coding for intestinal
lactase-phlorizin hydrolase
. The fragment overlaps the gene exon 1, part of the intron 1 and the 5'-upstream segment including a TATA-like box. Over 155 bp, the upstream segment shows 72% similarity with the corresponding sequence in human. Far upstream, the rat sequence exhibits a Calcium Responsive Element and putative binding sites for AP2, C/EBP, and
CTF
/NF. The intron contains a T-rich sequence that may cause DNA helix distortion.
...
PMID:The rat LPH gene 5' region: comparative structure with the human gene. 133 33
