Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.108 (
lactase
)
2,133
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The frequency of
lactase
persistence varies widely in human populations. Study showed that the T allele of a C/T transition 13910bp upstream from exon 1 of
lactase
gene (LCT) was completely associated with
lactase
persistence in a Finnish population. To evaluate if the frequency of -13910T allele was in concordance with the
lactase
persistence in northern Chinese populations, in this study, we used
Polymerase
Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) to detect the
lactase
-13910T allelic frequency in 5 northern Chinese populations for the first time. Results showed that the T allele frequency was low in these populations and that it did not match the
lactase
persistence phenotype in these populations. Therefore the -13910T allelic frequency can not serve as a predictor of the
lactase
persistence in these populations and this suggests the existence of other possible mechanisms of lactose tolerance in Chinese populations.
...
PMID:The lactase gene -13910T allele can not predict the lactase-persistence phenotype in north China. 1804 17
