Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.108 (lactase)
 2,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of bombesin on the postnatal development of the gastrointestinal tract was examined in New Zealand white rabbits. Bombesin (1.25, 12.5, 30 micrograms/kg body weight) or vehicle was administered intraperitoneally to suckling rabbits for 13 days starting on day 4 of life. The animals were killed at day 17. There was no significant effect of bombesin at doses of 1.25 or 12.5 micrograms/kg in any region of the gut studied. Bombesin administered at 30 micrograms/kg induced a widespread trophic effect in the gastrointestinal tract characterized by significant increases in the wet weight of the stomach, liver and whole small intestine, as well as in 10-cm segments of the proximal, middle, and distal small intestine. There was also a significant increase in the mucosal weight of 10-cm segments of the proximal, middle and distal small intestine, and the colon in the bombesin-treated group. Bombesin significantly increased the protein and DNA contents of the liver, the fundus of stomach, all segments of the small intestine and the distal colon. Maximal stimulation was seen in DNA content, suggesting that bombesin has a primarily hyperplastic effect. Bombesin increased the activities of small intestinal sucrase and maltase but not lactase. Bombesin did not alter hepatic glucokinase activity. These findings suggest that bombesin can promote the growth of the neonatal rabbit gastrointestinal tract and liver.
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PMID:Effect of bombesin on the development of the neonatal rabbit gastrointestinal tract. 156 36

The effect of oral folic acid on jejunal glycolytic enzyme activity in five fasting obese patients and in three normal male volunteers on a constant 3000 cal diet was studied. The glycolytic enzymes, fructokinase, hexokinase, glucokinase, fructose-1-phosphate aldolase, and fructose diphosphate aldolase, and the disaccharidases, sucrase, maltase, and lactase were measured. In both the fasting patients and the normal volunteers, oral folic acid significantly increased the jejunal glycolytic enzyme activities but had no effect on disaccharidase activity. When oral folic acid was discontinued in the normal volunteers, the glycolytic enzyme activities returned to control values. In the obese patients, refeeding and folic acid caused a further increase in glycolytic enzyme activities above that seen with fasting and folic acid. In contrast to oral folic acid, intramuscular folic acid, oral vitamin B(12), and oral tetracycline had no effect on glycolytic enzyme activities. These studies demonstrate that oral folic acid which is neither a substrate nor a coenzyme of these enzymes, increases human jejunal glycolytic enzyme activity in a specific fashion. This would appear to be an action of oral folic acid which has not been recognized previously.
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PMID:Regulation of human jejunal glycolytic enzymes by oral folic acid. 582 69

The activity of certain enzymes of the energy producing metabolism of the cytoplasmic and mitochondrial compartment and of disaccharidases was determined in jejunal biopsies of 24 chronic alcoholics (CA) and 10 non-alcoholic control subjects (C). The activity of glucokinase, an enzyme of glycolysis, was markedly (44%, p less than 0.05) increased in the biopsies obtained from CA, while the activity of fructose bisphosphatase, an enzyme of gluconeogenesis, was significantly (p less than 0.05) depressed in CA when compared to C. The activity of other glycolytic enzymes was not affected in CA. The activity of L-alanine amino-transferase was lower in CA (p less than 0.05). A reduction was also seen for mean succinate dehydrogenase activity in CA (-30%), however, this difference was not statistically significant. The mean activity of lactase, maltase and sucrase was comparable in both groups.
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PMID:Activities of cytoplasmic, mitochondrial and brush border enzymes in jejunal mucosa of chronic alcoholics. 628 1